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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Almajidi, Yasir Qasim
in Cooperation with on an Cooperation-Score of 37%
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Publications (3/3 displayed)
- 2023Optimization of removal of sulfonamide antibiotics by magnetic nanocomposite from water samples using central composite designcitations
- 2022Levofloxacin Adsorption onto MWCNTs/CoFe2O4 Nanocomposites: Mechanism, and Modeling Using Non-Linear Kinetics and Isotherm Equationscitations
- 2020Preparation and in vitro characterization of pediatric fast dissolving strip of dexchlorpheniramine maleate
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article
Preparation and in vitro characterization of pediatric fast dissolving strip of dexchlorpheniramine maleate
Abstract
Objective: The current work was conducted with the aim of preparing rapidly dissolving strips of dexchlorpheniramine maleate to improve pediatric patient adherence for the best pharmaceutical reaction through the first-pass hepatic metabolism bypass. Methods: The oral strip was prepared using various polymers hydroxypropyl methylcellulose (HPMC E15, HPMC K4M, and polyvinyl alcohol) using solvent casting methodology. Various types of plasticizers polyethylene glycol (PEG 400 and propylene glycol) have been used to raise the features of the strip preparation polymer. Results: From this work, formula 3, consisting of 360 mg HPMC E15 as a polymer and 1 ml PEG 400 as a plasticizer, offers acceptable formulation characteristics and rapid drug release (100%) at 10 min compared to the Polaramine®(Schering-Plough) tablets (66.18%) on the market. Conclusion: The optimum formula (F3) has been chosen to prepare rapidly dissolving strips to be useful for pediatric drug dosage by offering quicker release and better patient compliance. KEY WORDS: Hydroxypropyl methylcellulose E15, Pediatric, Polyethylene glycol 400, Strip