| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Hardy, John George
Lancaster University
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (10/10 displayed)
- 2022Li-Doped Bioactive Ceramics: Promising Biomaterials for Tissue Engineering and Regenerative Medicinecitations
- 2021Analysis of pyomelanin formation
- 2021Wirelessly triggered bioactive molecule delivery from degradable electroactive polymer filmscitations
- 2020Electroactive scaffolds and methods of using electroactive scaffolds
- 2020Electrical modification of aligned electrospun silk fibroin via interpenetrating polymer network of PEDOT:PSS for peripheral nerve regeneration.
- 2020Bioactive Silver Phosphate/Polyindole Nanocompositescitations
- 2019Optimizing Nanohydroxyapatite Nanocomposites for Bone Tissue Engineeringcitations
- 2019Photoinitiating polymerisable composition
- 2016Towards Robust Electroactive Biomaterials
- 2010Composite materials based on silk proteinscitations
Places of action
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document
Analysis of pyomelanin formation
Abstract
The accumulation of homogentisic acid (HGA) in patients with alkaptonuria is associated with the concomitant deposition of pigments contain significant amounts of polymerised HGA (polyHGA) in the bodily tissues of the patients. The polymerisation of HGA under various different conditions in vitro was investigated to attempt to understand if there is a correlation between the conditions and rate of pigment deposition in vivo. In this study, we applied a selection of different analytical chemistry techniques including: nuclear magnetic resonance spectroscopy (NMR), high-performance liquid chromatography (HPLC), gel permeation chromatography (GPC), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDX), UV-visible spectroscopy (UV-visible) and electron paramagnetic resonance (EPR). We observed condition-dependent polyHGA formation, and are currently correlating these findings with literature data (e.g. histological studies) to understand polyHGA pigment deposition inside specific tissues in the body.