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Oberbek, Przemysław
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article
Three dimensional hybrid scaffolds for bone tissue engineering
Abstract
There is a growing need for bone regeneration due to various clinical bone diseases such as bone infections, bone tumors and bone loss by trauma. This can be reached by bone tissue engineering. The modern scaffolds should mimic cells native in vivo environment as closely as possible, support and enhance tissue repair. Scaffolds should also deliver biological factors that promote tissue healing and new tissue formation. Composite (biodegradable and bioresorbable polymer + bioceramic) scaffolds are developed as substrates for cells and allow tissue regeneration. In this study we investigated the structure and functional properties of patient specific, nanocomposited scaffolds for bone tissue engineering based on biodegradable polymer (PCL) and nanoceramics (HAp and TCP), produced by rapid prototyping (three dimensional 3D printing) method.