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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Figurska, M.
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In vivo degradation and wear of biomaterials in total joint replacement
Abstract
Over a million of total joint arthroplasty (TJA) surgeries are performed annually to improve quality of life of the patients by relieving pain and offering increased mobility via restoration of joint functions. However, the TJA fails after few years causing pain, reducing the joint range of movement, and finally resulting in a revision operation. The main reasons for the revision are degradation and failure of implant biomaterials. This study aims at development of biomaterials for joint replacements being more successful. A preliminary evaluation of the wear-related failure of polyethylene glenoid components on the basis of the retrieval examination and wear simulations were performed. Degradation of implant materials was also assessed based on examination of the mechanical properties of the retrieved prostheses. Host response to the wear products was also discussed. The amount of wear was measured according to ASTM standards and volumetrically by using a laser scanning system. Furthermore, the implant surfaces were analyzed by scanning electron microscopy (SEM). The effect of the in vivo degradation on material properties was evaluated based on nanoindentation using of atomic force microscope (AFM).The significant wear evidence was found in the present study. The volumetric wear rate varied from 6.9 to 30.4 mm3/yr. The maximum linear wear rates exceed 0.2 mm/yr. Multidirectional scratchces, flakes, pitting areas ,and surface microcracks, which most likely result from subsurface fatigue, were observed in the SEM analysis. Based on the nanoiudentation results, it was found that the mechanical properties have changed due to degradation process of the polymeric implants.From this study, it can be concluded that significant polyethylene wear and degradation do appear in TJA and may contribute to limited long-term survivorship of the implants.