| People | Locations | Statistics |
|---|---|---|
| Naji, M. |
| |
| Motta, Antonella |
| |
| Aletan, Dirar |
| |
| Mohamed, Tarek |
| |
| Ertürk, Emre |
| |
| Taccardi, Nicola |
| |
| Kononenko, Denys |
| |
| Petrov, R. H. | Madrid |
|
| Alshaaer, Mazen | Brussels |
|
| Bih, L. |
| |
| Casati, R. |
| |
| Muller, Hermance |
| |
| Kočí, Jan | Prague |
|
| Šuljagić, Marija |
| |
| Kalteremidou, Kalliopi-Artemi | Brussels |
|
| Azam, Siraj |
| |
| Ospanova, Alyiya |
| |
| Blanpain, Bart |
| |
| Ali, M. A. |
| |
| Popa, V. |
| |
| Rančić, M. |
| |
| Ollier, Nadège |
| |
| Azevedo, Nuno Monteiro |
| |
| Landes, Michael |
| |
| Rignanese, Gian-Marco |
|
Garric, Xavier
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (13/13 displayed)
- 2024Fabrication and characterization of thin self-rolling film for anti-inflammatory drug deliverycitations
- 2024Ultrasensitive In Vitro and Ex Vivo Tracking of 13 C-Labeled PEG–PLA Degradation Products by MALDI-TOF Mass Spectrometrycitations
- 2024Biodegradable Tyramine Functional Gelatin/6 Arms-PLA Inks Compatible with 3D Two Photon-Polymerization Printing and Meniscus Tissue Regenerationcitations
- 2023Syntheses of biodegradable graft copolymers from sodium caseinate and poly ɛ-caprolactone or poly lactic acid. Applications to the compatibilization of sodium caseinate/polyester blendscitations
- 2023STAR-SHAPED POLYMERS FUNCTIONALIZED BY A CATECHOL DERIVATIVE AND USES THEREOF
- 2022Towards scarless healing with the use of hybrid collagen-based dermal substitutes: a study on their contraction, physical and biological properties over time
- 2022Poly(Lactic Acid)-Based Graft Copolymers: Syntheses Strategies and Improvement of Properties for Biomedical and Environmentally Friendly Applicationscitations
- 2022Poly(Lactic Acid)-Based Graft Copolymers: Syntheses Strategies and Improvement of Properties for Biomedical and Environmentally Friendly Applications ; Poly(Lactic Acid)-Based Graft Copolymers: Syntheses Strategies and Improvement of Properties for Biomedical and Environmentally Friendly Applications: A Reviewcitations
- 2021Long-term in vivo performances of polylactide/iron oxide nanoparticles core–shell fibrous nanocomposites as MRI-visible magneto-scaffoldscitations
- 2021Electrospun microstructured PLA-based scaffolds featuring relevant anisotropic, mechanical and degradation characteristics for soft tissue engineeringcitations
- 2016Modelling of mechanical properties of a PLA-b-PEG-b-PLA biodegradable triblock copolymer during hydrolytic degradation
- 2016Redox Reducible and Hydrolytically Degradable PEG–PLA Elastomers as Biomaterial for Temporary Drug-Eluting Medical Devicescitations
- 2011Mild Methodology for the Versatile Chemical Modifi cation of Polylactide Surfaces: Original Combination of Anionic and Click Chemistry for Biomedical Applicationscitations
Places of action
| Organizations | Location | People |
|---|
document
Modelling of mechanical properties of a PLA-b-PEG-b-PLA biodegradable triblock copolymer during hydrolytic degradation
Abstract
PLA-based biodegradable copolymers are used in many biomedical applications such as temporary implantable devices. Especially, PLA-b-PEG-b-PLA is an excellent candidate for tissue engineering applications. Indeed, it has a good biocompatibility and possesses both mechanical properties of PLA and hydrophilicity of PEG, allowing good properties and degradation time modulation. The main degradation process, for this type of polymers is the hydrolysis of ester links. After the diffusion of water into the polymer bulk, the hydrolysis reaction breaks the polymeric bonds. Modelling of mechanical properties evolution of biodegradable polymers is essential in order to design devices.The aim of this study is to explore and model the viscoelastic properties evolution of a PLA-b-PEG-b-PLA biodegradable copolymer during hydrolytic degradation. The mass decrease, the number average molecular weight and the mechanical properties were studied during 7 degradation weeks. Tensile and relaxation tests in a liquid bath at 37°C were realized at different states of degradation. Stress relaxation is observed, highlighting a viscoelastic behavior for every degradation state. Moreover, the polymer suffers a loss of mechanical properties in the course of degradation. In order to model viscoelastic properties, a generalized Maxwell model is used. This model is first identified on results obtained for non degraded material. Then, based on the invariance of the normalized relaxation curves experimentally observed for the degraded materials, a degradation variable is introduced in the model. Predictions of the model are then compared to experimental results in the course of degradation. The abilities and limits of the model are discussed.