| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Vollebregt, Sten
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Topics
Publications (14/14 displayed)
- 2023The sensitivity enhancement of TiO<sub>2</sub>-based VOCs sensor decorated by gold at room temperaturecitations
- 2022Patterning of fine-features in nanoporous films synthesized by spark ablationcitations
- 2022Multilayer CVD graphene electrodes using a transfer-free process for the next generation of optically transparent and MRI-compatible neural interfacescitations
- 2022Multilayer CVD graphene electrodes using a transfer-free process for the next generation of optically transparent and MRI-compatible neural interfacescitations
- 2022Enhancement of Room Temperature Ethanol Sensing by Optimizing the Density of Vertically Aligned Carbon Nanofibers Decorated with Gold Nanoparticlescitations
- 2022Hydrogenated Amorphous Silicon Carbidecitations
- 2020Infrared absorbance of vertically-aligned multi-walled CNT forest as a function of synthesis temperature and timecitations
- 2020Soft, flexible and transparent graphene-based active spinal cord implants for optogenetic studies
- 2020Vertically-Aligned Multi-Walled Carbon Nano Tube Pillars with Various Diameters under Compressioncitations
- 2020Toward a Self-Sensing Piezoresistive Pressure Sensor for all-SiC Monolithic Integrationcitations
- 2019Towards an Active Graphene-PDMS Implant
- 2019Growth of multi-layered graphene on molybdenum catalyst by solid phase reaction with amorphous carboncitations
- 2018Effects of Conformal Nanoscale Coatings on Thermal Performance of Vertically Aligned Carbon Nanotubescitations
- 2018Wafer Level Through Polymer Optical Vias (TPOV) Enabling High Throughput of Optical Windows Manufacturing
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document
Soft, flexible and transparent graphene-based active spinal cord implants for optogenetic studies
Abstract
Patients affected by spinal cord injuries (SCI) are usually unable to perform trivial motor activities and thus, for therapeutic purposes, epidural spinal cord stimulation (ESCS) is currently used. Moreover, more exploratory research, using optogenetics, is being conducted in rodents for a better understanding of the mechanisms that occur while delivering specific therapies. However, the availability of tailored neurotechnologies for such experiments is limited.This work reports the development and characterization of flexible, active spinal cord implants with optogenetic compatibility1,2 (Fig.1). A scalable and reproducible microfabrication process has been developed, using graphene3, a transparent, flexible and conductive material, to form the electrodes and interconnects of the implant. Small and thin4 electronic chips were assembled via flip-chip bonding processes either on graphene or on metal-on-graphene layers. Soft, polymeric encapsulation was employed to sustain the high flexibility and transparency of the implant. The result is an active prototype consisting of a multi-layered graphene structure between two polymeric-based encapsulation layers, with thin chips integrated on the implant and test pads for interconnection to the outside world.Raman spectroscopy and optical transmittance were employed for the characterization of the graphene layer while cyclic voltammetry and electrochemical impedance spectroscopy were performed to benchmark the electrical properties of the device. The assembly process of the chips was evaluated using four-point electrical measurements.In this work, the first transparent, graphene-based active implants have been developed (Fig. 2 and Fig. 3). The prototypes were extensively characterized and the results showed a transparency of ~80 % as well as no deterioration over time when soaked in saline solution or when bent under various angles. The graphene electrodes showed an impedance of ~8 kΩ at 1 kHz frequencies and the resistance after the bonding process ranged from 10 mΩ up to 16 Ω for individual connections, depending on the substrate used