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Naji, M. |
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Motta, Antonella |
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Aletan, Dirar |
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Mohamed, Tarek |
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Ertürk, Emre |
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Taccardi, Nicola |
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Kononenko, Denys |
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Petrov, R. H. | Madrid |
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Alshaaer, Mazen | Brussels |
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Bih, L. |
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Casati, R. |
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Muller, Hermance |
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Kočí, Jan | Prague |
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Šuljagić, Marija |
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Kalteremidou, Kalliopi-Artemi | Brussels |
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Azam, Siraj |
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Ospanova, Alyiya |
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Blanpain, Bart |
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Ali, M. A. |
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Popa, V. |
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Rančić, M. |
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Ollier, Nadège |
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Azevedo, Nuno Monteiro |
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Landes, Michael |
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Rignanese, Gian-Marco |
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Knowles, Jc
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (23/23 displayed)
- 2021Mussel Inspired Chemistry and Bacteria Derived Polymers for Oral Mucosal Adhesion and Drug Delivery
- 2021Antibacterial effect of titanium dioxide-doped phosphate glass microspheres filled total-etch dental adhesive on S. mutans biofilm
- 2020Advanced biocomposites of poly(glycerol sebacate) and β-tricalcium phosphate by in situ microwave synthesis for bioapplication
- 2020Synthesis, Characterisation and 3D Printing of an Isosorbide Based, Light Curable, Degradable Polymer for Potential Application in Maxillofacial Reconstruction
- 2020Mesoporous Phosphate-Based Glasses Prepared via Sol–Gel
- 2020Nano-graphene oxide/polyurethane nanofibers: mechanically flexible and myogenic stimulating matrix for skeletal tissue engineering
- 2019Combined Effects of Nanoroughness and Ions Produced by Electrodeposition of Mesoporous Bioglass Nanoparticle for Bone Regeneration
- 2019Antibacterial Copper-Doped Calcium Phosphate Glasses for Bone Tissue Regeneration
- 2018A reversible fluorescent probe for monitoring Ag(I) ions
- 2017Highly elastomeric poly(3-hydroxyoctanoate) based natural polymer composite for enhanced keratinocyte regeneration
- 2016The effect of platform switching on the levels of metal ion release from different implant-abutment couples
- 2016Electrohydrodynamic encapsulation of cisplatin in poly (lactic-co-glycolic acid) nanoparticles for controlled drug delivery
- 2016Degradation of zinc containing phosphate-based glass as a material for orthopedic tissue engineering
- 2016Dissolution and drug release profiles of phosphate glasses doped with high valency oxides
- 2014Biological performance of titania containing phosphate-based glasses for bone tissue engineering applications
- 2014Sequential identification of a degradable phosphate glass scaffold for skeletal muscle regeneration
- 2014Optical and photocatalytic behaviours of nanoparticles in the Ti-Zn-O binary systemcitations
- 2011Introducing stable microgrooves in to fluid-leaving surface of plastic compressed collagen by embossing
- 2011A review of the structure of human and bovine dental hard tissues and their physicochemical behaviour in relation to erosive challenge and remineralisation
- 2008Development of conical soluble phosphate glass fibres for directional generation of microchannels in dense collagen implants
- 2005Biocompatible phosphate glass fibre scaffolds
- 2004Biocompatible phosphate glass fibre scaffolds engineering of the hard/ soft tissue interface
- 2000Structural insights of glass-reinforced hydroxyapatite composites by Rietveld refinementcitations
Places of action
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article
Sequential identification of a degradable phosphate glass scaffold for skeletal muscle regeneration
Abstract
© 2012 John Wiley & Sons, Ltd.Tissue engineering has the potential to overcome limitations associated with current management of skeletal muscle defects. This study aimed to sequentially identify a degradable phosphate glass scaffold for the restoration of muscle defects. A series of glass compositions were investigated for the potential to promote bacterial growth. Thereafter, the response of human craniofacial muscle-derived cells was determined. Glass compositions containing Fe4- and 5mol% did not promote greater Staphylococcus aureus and Staphylococcus epidermidis growth compared to the control (p>0.05). Following confirmation of myogenicity, further studies assessed the biocompatibility of glasses containing Fe5 mol%. Cells seeded on collagen-coated disks demonstrated comparable cellular metabolic activity to control. Upregulation of genes encoding for myogenic regulatory factors (MRFs) confirmed myofibre formation and there was expression of developmental MYH genes. The use of 3-D aligned fibre scaffolds supported unidirectional cell alignment and upregulation of MRF and developmental MYH genes. Compared to the 2-D disks, there was also expression of MYH2 and MYH7 genes, indicating further myofibre maturation on the 3-D scaffolds and confirming the importance of key biophysical cues.