| People | Locations | Statistics |
|---|---|---|
| Naji, M. |
| |
| Motta, Antonella |
| |
| Aletan, Dirar |
| |
| Mohamed, Tarek |
| |
| Ertürk, Emre |
| |
| Taccardi, Nicola |
| |
| Kononenko, Denys |
| |
| Petrov, R. H. | Madrid |
|
| Alshaaer, Mazen | Brussels |
|
| Bih, L. |
| |
| Casati, R. |
| |
| Muller, Hermance |
| |
| Kočí, Jan | Prague |
|
| Šuljagić, Marija |
| |
| Kalteremidou, Kalliopi-Artemi | Brussels |
|
| Azam, Siraj |
| |
| Ospanova, Alyiya |
| |
| Blanpain, Bart |
| |
| Ali, M. A. |
| |
| Popa, V. |
| |
| Rančić, M. |
| |
| Ollier, Nadège |
| |
| Azevedo, Nuno Monteiro |
| |
| Landes, Michael |
| |
| Rignanese, Gian-Marco |
|
Rosal, Roberto
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (5/5 displayed)
- 2023Identification and toxicity towards aquatic primary producers of the smallest fractions released from hydrolytic degradation of polycaprolactone microplasticscitations
- 2022Identification and toxicity towards aquatic primary producers of the smallest fractions released from hydrolytic degradation of polycaprolactone microplasticscitations
- 2022Modelling the Photodegradation of Marine Microplastics by Means of Infrared Spectrometry and Chemometric Techniquescitations
- 2021High performance of electrosprayed graphene oxide/TiO2/Ce-TiO2 photoanodes for photoelectrocatalytic inactivation of S. aureuscitations
- 2015Antimicrobial electrospun silver-, copper-and zinc-doped polyvinylpyrrolidone nanofibers
Places of action
| Organizations | Location | People |
|---|
article
Antimicrobial electrospun silver-, copper-and zinc-doped polyvinylpyrrolidone nanofibers
Abstract
Polyurethane ureas (PUU) are segmented polymers where soft and hard segments are separated in microphases. Usually, the soft segment is derived from a polyol and the hard segment from a diisocyanate and a chain extender. The PUU properties can be tuned in order to obtain biodegradable scaffolds with suitable mechanical properties for tissue engineering applications [1]. Electrospinning is a convenient technique for the production of nanofibrous scaffolds from a polymeric solution that mimic the extracellular matrix, thereby supporting cell attachment and growth [2]. The physico-chemical properties of the material used and the scaffold's architecture both provide cells with cues. In this work, we synthetized a PUU based on PCL-diol using CS as chain extender (PUU-CS) [3]. Molecular structure was analyzed by 1H NMR and FTIR. Thermogravimetric analysis was performed to examine the thermal stability. The PUU-CS was electrospun from solutions using a mixture of tetrahydrofuran and N, N-dimethylformamide as solvent. Randomly oriented and aligned fibres were collected on a static and on a rotating collector, respectively. Morphological properties were characterized by SEM and mechanical properties evaluated through tensile tests. Hydrolytic (phosphate buffer saline (PBS) solution) and enzymatic (lipase) degradation studies were carried out. The cytocompatibility of the PUU-CS fibre mats was evaluated using the extract method. A preliminary study of cell adhesion was also performed. Spectroscopic results confirmed that PUU-CS was successfully produced and is stable at least until 200 oC. Randomly oriented and aligned fibres with different mean diameters were obtained. Both types of fibre mats showed higher Young's modulus for the thinner fibres. Elongation at break was lower for the aligned fibre mats. No mass changes were observed in the mats during 3 months in PBS while significant degradation was observed in lipase. In vitro tests didn't demonstrate any toxicity of the extracts. Cells seeded on the mats were able to adhere. These properties make nanofiber mats based on PUU-CS good candidates for soft tissue engineering.