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Thoppe Rajendran, Sriram
Technical University of Denmark
in Cooperation with on an Cooperation-Score of 37%
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document
Artificial gut-on-a-disc platform to evaluate ph sensitive coatings of oral drug delivery devices
Abstract
RapidtestingofpHcoatingsoforaldrugdelivery(ODD) devicesisoftencomplexandtimeconsuming.A lab-on-a-disc(LoD)platformwasdevelopedwhichenablesdetectionofintegrityofpHcoatingsforuptofour differentpHs. Theplatform wasdesignedtoperfuse ODD devices through different pH inasequentialmanner,mimicking the pH variations in the gastrointestinal (GI) tract. The disintegration of pH coatings causes release of drugs, which in turn is used to monitor integrity of pH coatings. Combining ‘event-triggered’ flow control, based ondissolvablefilmwithelectrochemicaldetection,enablesaccelerated,real-timecharacterizationofODD devices.