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Naji, M. |
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Motta, Antonella |
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Aletan, Dirar |
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Mohamed, Tarek |
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Ertürk, Emre |
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Taccardi, Nicola |
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Kononenko, Denys |
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Petrov, R. H. | Madrid |
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Alshaaer, Mazen | Brussels |
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Bih, L. |
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Casati, R. |
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Muller, Hermance |
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Kočí, Jan | Prague |
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Šuljagić, Marija |
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Kalteremidou, Kalliopi-Artemi | Brussels |
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Azam, Siraj |
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Ospanova, Alyiya |
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Blanpain, Bart |
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Ali, M. A. |
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Popa, V. |
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Rančić, M. |
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Ollier, Nadège |
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Azevedo, Nuno Monteiro |
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Landes, Michael |
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Rignanese, Gian-Marco |
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Zór, Kinga
Technical University of Denmark
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (5/5 displayed)
- 20233D-printed Radiopaque Microdevices with Enhanced Mucoadhesive Geometry for Oral Drug Deliverycitations
- 2019Artificial gut-on-a-disc platform to evaluate ph sensitive coatings of oral drug delivery devices
- 2019Evaluation of the solid state form of tadalafil in sub-micron thin films using nanomechanical infrared spectroscopycitations
- 2018Injection-Molded Microfluidic Device for SERS Sensing Using Embedded Au-Capped Polymer Nanoconescitations
- 2016Comparison of Ultrasonic Welding and Thermal Bonding for the Integration of Thin Film Metal Electrodes in Injection Molded Polymeric Lab-on-Chip Systems for Electrochemistrycitations
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document
Artificial gut-on-a-disc platform to evaluate ph sensitive coatings of oral drug delivery devices
Abstract
RapidtestingofpHcoatingsoforaldrugdelivery(ODD) devicesisoftencomplexandtimeconsuming.A lab-on-a-disc(LoD)platformwasdevelopedwhichenablesdetectionofintegrityofpHcoatingsforuptofour differentpHs. Theplatform wasdesignedtoperfuse ODD devices through different pH inasequentialmanner,mimicking the pH variations in the gastrointestinal (GI) tract. The disintegration of pH coatings causes release of drugs, which in turn is used to monitor integrity of pH coatings. Combining ‘event-triggered’ flow control, based ondissolvablefilmwithelectrochemicaldetection,enablesaccelerated,real-timecharacterizationofODD devices.