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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Butera, S.
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article
Development and evaluation of a vaginal ring device for sustained delivery of HIV microbicides to non-human primate
Abstract
Background There is considerable interest in developing coitally indepen-dent, sustained release formulations for long-term administration of HIVmicrobicides. Vaginal ring devices are at the forefront of this formulationstrategy.Methods Non-medicated silicone elastomer vaginal rings were preparedhaving a range of appropriate dimensions for testing vaginal ?t in pig-tailed and Chinese rhesus macaques. Cervicovaginal proin?ammatorymarkers were evaluated. Compression testing was performed to comparethe relative ?exibility of various macaque and commercial human rings.Results All rings remained in place during the study period and no tissueirritation or signi?cant induction of cervicovaginal proin?ammatory mark-ers or signs of physical discomfort were observed during the 8-week studyperiod.Conclusions Qualitative evaluation suggests that the 25 · 5-mm ring pro-vided optimal ?t in both macaque species. Based on the results presentedhere, low-consistency silicone elastomers do not cause irritation in maca-