| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Mccoy, Clare
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (12/12 displayed)
- 2023A multipurpose ‘CZL’ vaginal ring for non-hormonal contraception and STI/HIV prevention
- 2021Custom silicone elastomers for improved mechanical performance and reduced hormone binding in a dapivirine/levonorgestrel vaginal ring
- 2021Formulation development of an ethylene vinyl acetate ring for sustained release of the experimental entry inhibitor DS003
- 2021Silicone elastomer formulations for improved performance of a multipurpose vaginal ring releasing dapivirine and levonorgestrelcitations
- 2019Post-use ring weight, residual drug content and drug depletion zone thickness as objective measures of user adherence to a contraceptive progesterone vaginal ringcitations
- 2019Towards a dapivirine and levonorgestrel multipurpose vaginal ring: Investigations into the reaction between levonorgestrel and addition-cure silicone elastomerscitations
- 2019Mechanical testing methods for drug-releasing vaginal ringscitations
- 2019In vitro release testing methods for drug-releasing vaginal ringscitations
- 2018Density Mediated Drug Release From Dapivirine Vaginal Rings Produced by Additive Manufacturing
- 2017Packing polymorphism of dapivirine and its impact on the performance of a dapivirine-releasing silicone elastomer vaginal ringcitations
- 2014Thermal properties and eutectic behaviour of dapivirine in combination with steroid hormones and other antiretrovirals
- 2009Development and evaluation of a vaginal ring device for sustained delivery of HIV microbicides to non-human primate
Places of action
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article
Development and evaluation of a vaginal ring device for sustained delivery of HIV microbicides to non-human primate
Abstract
Background There is considerable interest in developing coitally indepen-dent, sustained release formulations for long-term administration of HIVmicrobicides. Vaginal ring devices are at the forefront of this formulationstrategy.Methods Non-medicated silicone elastomer vaginal rings were preparedhaving a range of appropriate dimensions for testing vaginal ?t in pig-tailed and Chinese rhesus macaques. Cervicovaginal proin?ammatorymarkers were evaluated. Compression testing was performed to comparethe relative ?exibility of various macaque and commercial human rings.Results All rings remained in place during the study period and no tissueirritation or signi?cant induction of cervicovaginal proin?ammatory mark-ers or signs of physical discomfort were observed during the 8-week studyperiod.Conclusions Qualitative evaluation suggests that the 25 · 5-mm ring pro-vided optimal ?t in both macaque species. Based on the results presentedhere, low-consistency silicone elastomers do not cause irritation in maca-