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| Petrov, R. H. | Madrid |
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| Azevedo, Nuno Monteiro |
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Eckstein, Daniel
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document
Physical and chemical characterization of synthetic bone mineral ink for robocasting applications
Abstract
<p>Introduction: Yearly, millions of individuals suffer from bone defects caused by trauma or congenital disease<sup>1</sup>. The “gold standard” is to fill these boney defects with an autologous bone graft, however, issues of availability, morbidity, secondary surgical site and customizability have lead to the use of synthetic grafting modalities<sup>2</sup>. The novel formulation of Synthetic Bone Mineral (SBM) is a viable option as a synthetic graft material. SBM is a carbonated hydroxyapatite with ionic substitutions of Zinc, chloride, fluoride, and magnesium, which closely mimics the chemistry of biological apatite<sup>3</sup>. Robocasting technology offers the flexibility in bone graft customization, geometry and composition. Our team has leveraged 3D printing technology to manufacture custom scaffolds using various bioactive ceramic materials without the need for a mold<sup>4</sup>. The objective of this work was to first synthesize a colloidal gel composed of SBM, then which would be suitable for Robocasting applications and characterize it chemically and mechanically.</p>