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Larranaga-Vega, Ane
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document
Comparative in vitro study of 3D robocasting scaffolds using beta tricalcium phosphate and synthetic bone mineral
Abstract
<p>Introduction: Bone defects may occur due to various congenital disorders, traumas, tumors, or oncological resections. As a treatment option, bioactive ceramic-based graft materials have been used to regenerate bone<sup>1</sup>. One example of a bioceramic material used to regenerate bone is Synthetic Bone Mineral (SBM), which is described as a carbonate hydroxyapatite with ionic substitutions such as F<sup>-</sup>, Zn<sup>2+</sup> and Mg<sup>2+</sup>. A novel formulation of SBM has been studied, showing successful results; improving bone density and promoting bone formation<sup>2</sup>. SBM colloidal gel has been fabricated for robocasting applications<sup>3</sup>. A robocasting 3D printer is used to customize ceramic structures for building scaffolds for bone regeneration<sup>4</sup>. The objective of this work is to compare the in vitro performance of printed 3D scaffolds made from two different bioceramic materials, β-tricalcium phosphate (β-TCP) and SBM.</p>