| People | Locations | Statistics |
|---|---|---|
| Naji, M. |
| |
| Motta, Antonella |
| |
| Aletan, Dirar |
| |
| Mohamed, Tarek |
| |
| Ertürk, Emre |
| |
| Taccardi, Nicola |
| |
| Kononenko, Denys |
| |
| Petrov, R. H. | Madrid |
|
| Alshaaer, Mazen | Brussels |
|
| Bih, L. |
| |
| Casati, R. |
| |
| Muller, Hermance |
| |
| Kočí, Jan | Prague |
|
| Šuljagić, Marija |
| |
| Kalteremidou, Kalliopi-Artemi | Brussels |
|
| Azam, Siraj |
| |
| Ospanova, Alyiya |
| |
| Blanpain, Bart |
| |
| Ali, M. A. |
| |
| Popa, V. |
| |
| Rančić, M. |
| |
| Ollier, Nadège |
| |
| Azevedo, Nuno Monteiro |
| |
| Landes, Michael |
| |
| Rignanese, Gian-Marco |
|
Kumar, Sandeep
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (23/23 displayed)
- 2025Multifunctional characterization of high tensile strength PEO/PVP blend based composites with InAs nanowire fillers for structural sodium ion batteries
- 2024Meta-Learning for Real-World Class Incremental Learning: A Transformer-Based Approach
- 2023Influence of single nucleotide polymorphism in the <i>IGF-1</i> gene on performance and conformation traits in Munjal sheepcitations
- 2023Artificial synaptic characteristics of PVA:ZnO nanocomposite memristive devicescitations
- 2023Simultaneous realization of FIR-based multimode optical thermometry and photonic molecular logic gates in Er<sup>3+</sup> and Yb<sup>3+</sup> co-doped SrTiO<sub>3</sub> phosphorcitations
- 2022Feasibility Analysis of Machining Cobalt-Chromium Alloy (Stellite-6) Using TiN Coated Binary Insertscitations
- 2022Mathematical Expressions Model to forecast for Chloride Ion Penetration and Comp. Strength of Recycled Coarse Aggregate Concrete Incorporating Meta-kaolincitations
- 2022Strength Evaluation of Functionalized MWCNT-Reinforced Polymer Nanocomposites Synthesized Using a 3D Mixing Approachcitations
- 2022High performance computing for modelling of stereolithography process
- 2021A nanostructured cellulose-based interphase layer to enhance the mechanical performance of glass fibre-reinforced polymer compositescitations
- 2021Topological phonons in an inhomogeneously strained silicon-2: Evidence of spin-momentum locking
- 2021Topological phonons in an inhomogeneously strained silicon-4: Large spin dependent thermoelectric response and thermal spin transfer torque due to topological electronic magnetism of phonons
- 2020Investigation on the influence of multi-step processing on the mechanical and thermal properties of cellulose reinforced EVOH compositescitations
- 2020High performance multiscale glass fibre epoxy composites integrated with cellulose nanocrystals for advanced structural applicationscitations
- 2020Flexoelectric effect mediated spin-to-charge conversion at amorphous-Si thin film interfaces
- 20201D semiconductor nanowires for energy conversion, harvesting and storage applicationscitations
- 20201D semiconductor nanowires for energy conversion, harvesting and storage applicationscitations
- 2018Recent Advances in Discotic Liquid Crystal-Assisted Nanoparticlescitations
- 2017High electrochemical performance flexible solid-state supercapacitor based on Co-doped reduced graphene oxide and silk fibroin composites.citations
- 2017Carboxybetaine-modified succinylated chitosan-based beads encourage pancreaticβ-cells (Min-6) to form islet-like spheroids under in vitro conditionscitations
- 2017Disturbed Flow Promotes Arterial Stiffening Through Thrombospondin-1citations
- 2015Influence of processing conditions on properties of poly (vinyl acetate)/ cellulose nanocrystals nanocomposites
- 2014Thermal properties and eutectic behaviour of dapivirine in combination with steroid hormones and other antiretrovirals
Places of action
| Organizations | Location | People |
|---|
document
Thermal properties and eutectic behaviour of dapivirine in combination with steroid hormones and other antiretrovirals
Abstract
Background: Combination drug products can display thermal behaviour that is more complex than for the corresponding single drug products. For example, the contraceptive vaginal ring (VR) Nuvaring contains a eutectic (lowest melting) composition of etonogestrel (ETN) and ethinyl estradiol. Here we report the predisposition of dapivirine (DPV) to form reduced melting/eutectic mixtures when combined with other contraceptive hormones and antiretrovirals, and discuss the implications for development of combination microbicide and multipurpose prevention technology (MPT) products.<br/>Methods: Binary mixtures of DPV with darunavir (DRV), levonorgestrel (LNG), ETN or maraviroc (MVC) were prepared either by physical mixing or by solvent evaporation. Selected binary mixtures were also incorporated into silicone elastomer (SE) VR devices. Thermal behavior of the mixtures was analyzed using differential scanning calorimetry (DSC) operating in standard heating ramp mode (10 °C/min). DSC data were used to construct two component phase diagrams for each binary system.<br/>Results: Drug mixtures typically showed reduced melting transitions for both drug components, with clear evidence for a eutectic mixture at a well-defined intermediate composition. Eutectic temperatures and compositions for the various mixtures were: 40% DPV / 60% ETN - 170°C; 25% DPV / 75% MVC - 172°C; 65% DPV / 35% LNG - 192°C. In each case, the eutectic composition was also detected when the drug mixtures were incorporated into SE VRs. For the DPV/DRV system, the thermal behaviour is complicated by desolvation from the darunavir ethanolate polymorph.<br/>Conclusions: When DPV is combined with small molecular weight hydrophobic drugs, the melting temperature for both drugs is typically reduced to a degree dependent on the composition of the mixture. At specified compositions, a low melting eutectic system results. The formation of eutectic behavior in binary drug systems needs to be carefully characterised in order to define product performance and drug release.