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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Bonfield, W.
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (17/17 displayed)
- 2012Cobalt-based orthopaedic alloys: Relationship between forming route, microstructure and tribological performance
- 2005In vivo assessment of hydroxyapatite and silicate-substituted hydroxyapatite granules using an ovine defect model
- 2004Ultrastructural comparison of dissolution and apatite precipitation on hydroxyapatite and silicon-substituted hydroxyapatite in vitro and in vivocitations
- 2003Calcium phosphate coatings obtained by Nd : YAG laser cladding: Physicochemical and biologic propertiescitations
- 2003Comparison of sintering and mechanical properties of hydroxyapatite and silicon-substituted hydroxyapatite
- 2002Characterization of new acrylic bone cements prepared with oleic acid derivativescitations
- 2002Preparation and characterization of magnesium/carbonate co-substituted hydroxyapatitescitations
- 2002Anisotropic mechanical properties of oriented HAPEX™citations
- 2002Friction and wear of hydroxyapatite reinforced high density polyethylene against the stainless steel counterfacecitations
- 2002Effect of silicon substitution on the sintering and microstructure of hydroxyapatite
- 2001Production of calcium phosphate coatings on Ti6Al4V obtained by Nd : yttrium-aluminum-garnet laser cladding
- 2001Effect of powder characteristics on the sinterability of hydroxyapatite powderscitations
- 2001Calcining influence on the powder properties of hydroxyapatitecitations
- 2001Particle size effects on apatite-wollastonite glass crystallisation
- 2000Dynamic mechanical characterization of hydroxyapatite reinforced polyethylene: Effect of particle sizecitations
- 2000Analysis of apatite layers on glass-ceramic particulate using FTIR and FT-Raman spectroscopy
- 2000Influence of phase purity on the in vivo response to hydroxyapatite
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document
Influence of phase purity on the in vivo response to hydroxyapatite
Abstract
<p>Two batches of calcium phosphate implants, termed HA1 and HA2 were prepared with calcium to phosphorus ratios of 1.67 and 1.70 respectively. XRD demonstrated that the HA1 implants were composed of phase pure hydroxyapatite, while the phase composition of the HA2 implants contained approximately 5% calcium oxide with the balance being hydroxyapatite. Sintered cylindrical implants, 3 mm in diameter, were prepared from each of the powders, containing slots I mm wide x 2 mm deep in one circular face. The implants were implanted laterally in the distal femur of 6 month old New Zealand white rabbits for a period of 3 weeks.</p><p>Subsequent histological evaluation demonstrated that the presence of the CaO impurity phase significantly reduced the osteoconductivity, as demonstrated by minimal penetration of new bone within HA2 implant slots and a significant reduction in direct bone apposition on any of the HA2 implant surfaces as compared with HA1 implants. This study has confirmed the need for precise control of the phase purity of hydroxyapatite based bioceramics for optimal biological performance.</p>