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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Gibson, Iain
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (23/23 displayed)
- 2020Natural and Synthetic Hydroxyapatitescitations
- 2020Ceramics, Glasses, and Glass-Ceramicscitations
- 2011Synthesis of Bioceramic Compositions
- 2008Optimisation of the aqueous precipitation synthesis of silicatesubstituted hydroxyapatite
- 2008Optimisation of the aqueous precipitation synthesis of silicate-substituted hydroxyapatite
- 2007Comparison of Carbonate Hydroxyapatite with and without Sodium Co-Substitutioncitations
- 2007Synthesis of Novel High Silicate-Substituted Hydroxyapatite by Co-Substitution Mechanismscitations
- 2006The uptake of titanium ions by hydroxyapatite particles-structural changes and possible mechanismscitations
- 2005In vivo assessment of hydroxyapatite and silicate-substituted hydroxyapatite granules using an ovine defect model
- 2003Calcium phosphate coatings obtained by Nd : YAG laser cladding: Physicochemical and biologic propertiescitations
- 2003Comparison of sintering and mechanical properties of hydroxyapatite and silicon-substituted hydroxyapatite
- 2002Ferroelasticity and hysteresis in LaCoO3 based perovskites
- 2002Porous glass reinforced hydroxyapatite materials produced with different organic additivescitations
- 2002Preparation and characterization of magnesium/carbonate co-substituted hydroxyapatitescitations
- 2002Characterisation of mono- and biphasic calcium phosphates granules
- 2002Effect of silicon substitution on the sintering and microstructure of hydroxyapatite
- 2001Production of calcium phosphate coatings on Ti6Al4V obtained by Nd : yttrium-aluminum-garnet laser cladding
- 2001Effect of chemical composition on hydrophobicity and zeta potential of plasma sprayed HA/CaO-P2O5 glass coatingscitations
- 2001Effect of powder characteristics on the sinterability of hydroxyapatite powderscitations
- 2001Calcining influence on the powder properties of hydroxyapatitecitations
- 2001Adsorption and release studies of sodium ampicillin from hydroxyapatite and glass-reinforced hydroxyapatite compositescitations
- 2001Particle size effects on apatite-wollastonite glass crystallisation
- 2000Influence of phase purity on the in vivo response to hydroxyapatite
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document
Influence of phase purity on the in vivo response to hydroxyapatite
Abstract
<p>Two batches of calcium phosphate implants, termed HA1 and HA2 were prepared with calcium to phosphorus ratios of 1.67 and 1.70 respectively. XRD demonstrated that the HA1 implants were composed of phase pure hydroxyapatite, while the phase composition of the HA2 implants contained approximately 5% calcium oxide with the balance being hydroxyapatite. Sintered cylindrical implants, 3 mm in diameter, were prepared from each of the powders, containing slots I mm wide x 2 mm deep in one circular face. The implants were implanted laterally in the distal femur of 6 month old New Zealand white rabbits for a period of 3 weeks.</p><p>Subsequent histological evaluation demonstrated that the presence of the CaO impurity phase significantly reduced the osteoconductivity, as demonstrated by minimal penetration of new bone within HA2 implant slots and a significant reduction in direct bone apposition on any of the HA2 implant surfaces as compared with HA1 implants. This study has confirmed the need for precise control of the phase purity of hydroxyapatite based bioceramics for optimal biological performance.</p>