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Clarke, M. T.
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article
In vivo assessment of hydroxyapatite and silicate-substituted hydroxyapatite granules using an ovine defect model
Abstract
The assessment of the longer-term in vivo response of a range of silicate-substituted hydroxyapatite (HA) ceramics using an ovine defect model was discussed. The phase pure HA, 0.8 wt. % silicate-substituted HA and 1.5 wt. % silicate-substituted HA were prepared by aqueous precipitation reactions. It was concluded that the bioactivity of HA granules was significantly enhanced by the substitution of 0.8 and 1.5 wt % silicate ions into the HA structure. The high-resolution transmission electron microscopy (HRTEM) studies demonstrated that the substitution of silicate ions increases the physiological dissolution rate of HA implants.