• Pye, S. D.
• Gatzoulis, L.
• Moran, C. M.
• Mcdicken, W. N.
• Sboros, Vassilis
• Averkiou, M.
• Anderson, T.
• Criton, A.

Abstract

<p>An in vitro system for the investigation of the behaviour of contrast microbubbles in an ultrasound field, that provides a full diagnostic range of settings, is yet to be presented in the literature. The evaluation of a good compromise of such a system is presented in this paper. It is based on (a) an HDI3000 ATL scanner (Bothell, WA, USA) externally controlled by a PC and (b) on the use of well-defined reference materials. The suspensions of the reference ultrasonic scattering material are placed in an anechoic tank. The pulse length ranges from 2 to 10 cycles, the acoustic pressure from 0.08 to 1.8 MPa, the transmit frequency from 1 to 4.3 MHz, and the receive frequency from 1 to 8 MHz. The collection of 256 samples of RF data, at an offset distance from the transducer face, was performed at 20 MHz digitization rate, which corresponds to approximately 1 cm depth in water. Two particle suspensions are also presented for use as reference scatterers for contrast studies: (a) a suspension of Orgasol((R)) (ELF Atochem, Paris, France) particles (similar to5 mum mean diameter) and (b) a suspension of Eccosphere((R)) (New Metals &amp; Chemicals Ltd, Essex, UK) particles (similar to 50 mum mean diameter). A preliminary experiment with the contrast agent Definity (DuPont Pharmaceutical Co, Waltham, MA) showed that the above two materials are suitable for use as a reference for contrast backscatter.</p>

Topics

• impedance spectroscopy
• experiment
• ultrasonic