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Ekanem, Ekanem
University of Bath
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (4/4 displayed)
- 2022Monodispersed Sirolimus-Loaded PLGA Microspheres with a Controlled Degree of Drug-Polymer Phase Separation for Drug-Coated Implantable Medical Devices and Subcutaneous Injectioncitations
- 2017Facile Production of Biodegradable Bipolymer Patchy and Patchy Janus Particles with Controlled Morphology by Microfluidic Routescitations
- 2015Structured Biodegradable Polymeric Microparticles for Drug Delivery Produced Using Flow Focusing Glass Microfluidic Devicescitations
- 2014Structured biodegradable microparticles produced using glass microfluidic flow focussing devices
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document
Structured biodegradable microparticles produced using glass microfluidic flow focussing devices
Abstract
<p>Herein is reported the production of biodegradable poly (lactic acid) (PLA) and poly (lactic-coglycolic acid) (PLGA) particles having modifiable internal and surface microstructures via single step emulsification using microfabricated 3D (axisymmetric) flow focusing glass capillary microfluidic devices and subsequent solvent evaporation. Controlled production of emulsion droplets was achieved and the morphology of particles produced after evaporation was investigated to ascertain its effect on hydrophobic drug encapsulation and release.</p>