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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Robertson, John
University of Strathclyde
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (21/21 displayed)
- 2022Halide Perovskites: Advanced Photovoltaic Materials Empowered by a Unique Bonding Mechanismcitations
- 2022Printability of pharmaceutical Fused Deposition Modeling (FDM) feedstock material
- 2021Halide Perovskites: Advanced Photovoltaic Materials Empowered by a Unique Bonding Mechanism
- 2019Use of terahertz-Raman spectroscopy to determine solubility of the crystalline active pharmaceutical ingredient in polymeric matrices during hot melt extrusioncitations
- 2018Carbon nanotube isolation layer enhancing in-liquid quality-factors of thin film bulk acoustic wave resonators for gravimetric sensing
- 2018Insulator-to-Metallic Spin-Filtering in 2D-Magnetic Tunnel Junctions Based on Hexagonal Boron Nitridecitations
- 2017Defect passivation of transition metal dichalcogenides via a charge transfer van der Waals interface.
- 2017Low temperature growth of fully covered single-layer graphene using a CoCu catalystcitations
- 2017Low temperature growth of fully covered single-layer graphene using a CoCu catalyst.
- 2016Modelling of co-rotating twin-screw extruders in the pharmaceutical industry I
- 2015High-K materials and metal gates for CMOS applications
- 2015Spatial variability in large area single and few-layer CVD graphene
- 2015Influence of packing density and surface roughness of vertically-aligned carbon nanotubes on adhesive properties of gecko-inspired mimetics.
- 2014Bio-inspired hierarchical polymer fiber-carbon nanotube adhesivescitations
- 2014The role of the sp2:sp3 substrate content in carbon supported nanotube growthcitations
- 2014The role of the sp 2 :sp 3 substrate content in carbon supported nanotube growthcitations
- 2012The phase of iron catalyst nanoparticles during carbon nanotube growthcitations
- 2007Diamond-like carbon for data and beer storagecitations
- 2006Periodic inclusion of room-temperature-ferromagnetic metal phosphide nanoparticles in carbon nanotubescitations
- 2005Materials science: The ultrasmoothness of diamond-like carbon surfacescitations
- 2004Hydrogen content estimation of hydrogenated amorphous carbon by visible Raman spectroscopycitations
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document
Modelling of co-rotating twin-screw extruders in the pharmaceutical industry I
Abstract
Twin-screw extruders are being increasingly applied in the pharmaceutical industry for the manufacture of solid dispersions. In particular, Hot Melt Extrusion (HME) is a viable manufacturing alternative for poorly soluble drugs that are difficult to process. This is due to the high shear stress applied in the process, which enhances mixing of the base polymer with the dispersed API. Delivery systems that can be obtained using this technology include pellets, granules, sustained release tablets and implants. Experiments for HME are typically very labour-intensive, involving the use of highly viscous polymers, high pressures, and require proper cleaning between runs. Identifying the critical experiments to perform based on model simulations would thus be highly desirable. Single-component modelling of twin-screw extrusion processes could be beneficial in the following areas: identifying optimal screw configurations, tracking the degree of melting and when identifying the area within the extruder where the polymer becomes completely melted.