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Rotenberg, A.
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document
Construction and evaluation of rodent-specific TMS coils
Abstract
Rodent models of transcranial magnetic stimulation (TMS) are crucial for understanding the cellular and molecular mechanisms underlying TMS induced plasticity in humans. However commercial coils used to stimulate rodents lack the spatial resolution used clinically. Here we describe two novel TMS coils designed for focal stimulation in rodents. Two circular coils (8 mm outer diameter) were constructed with either an air or pure iron core.Peak magnetic field strength for the air and iron-cores were 90mT and 120mT respectively, with the iron-core coil exhibiting less focality. Coil temperature and magnetic field stability for the two coils undergoing repetitive TMS (rTMS), were similar at1Hz but varied at 10Hz. To test the biological relevance of the coils, we applied rTMS in rodents to examine changes in cortical excitability (motor evoked potentials) and molecular markers (western blot and ELISA) implicated in TMS neuromodulation. Preliminary results suggest 5Hz rTMS delivered with the iron-core coil suppresses motor evoked potential amplitudes in anaesthetised rats. Analysis of molecular data is ongoing. Our results suggest the coils are suitable for the use in rodents and provide the opportunity to investigate the mechanisms underlying TMS in an experimental setting.