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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Ezzeddine, Alaa
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Publications (2/2 displayed)
- 2015Evaluation of multiple theranostic properties of polydopamine coated Fe0.65Co0.35@(Fe0.65Co0.35)3O4 nanocubes for cancer nanomedicinalapplication
- 2015Surface Modification of Multiwall Carbon Nanotubes with Cationic Conjugated Polyelectrolytes: Fundamental Interactions and Intercalation into Conductive Poly(methyl-methacrylate) Compositescitations
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document
Evaluation of multiple theranostic properties of polydopamine coated Fe0.65Co0.35@(Fe0.65Co0.35)3O4 nanocubes for cancer nanomedicinalapplication
Abstract
Theobjectiveofourworkwasthefabricationofsingletheranosticagentforcancer nanomedicine, which should be easily producible, cheap, biocompatible, spatially and temporally controllable and should have broader range of diagnostic and therapeutic modalities compared with previous works. Here we present the cost efficient and easy to scale-up, modified procedure of synthesis, controlled thin oxide shell formation and polydopamine coating with basic polymerization of dopamine hydrochloride in aqueous solution. Full characterization (HR-TEM, SEM, XRD, HR-TEM-EDAX, HR-TEM-SAED, SEM-EDAX, FTIR, UV-Vis-NIR, TGA, VSM) ofnovelsystemcomprisingofsub-micrometersizedFe0.65Co0.35@(Fe0.65Co0.35)3O4@PDA highly magnetic (with 226 emu/g value for the metal core Fe0.65Co0.35@(Fe0.65Co0.35)3O4) nanoparticles was done. In vitro MTT cell viability assay on HeLa cells showed no toxicity up to100 µg/ml of nanoparticles concentration. They are dual mode diagnostic agents with MRI (r2=186.44 mM-1s-1) and X-Ray CT contrasting properties. The HeLa cells was used in in vitro assays. Doxorubicin delivery to the nuclei (laser fluorescence confocal microscopy) and 55% of death (MTT assay) at the concentration of 10 µg/ml was registered. The release of doxorubicin was demonstrated pH sensitive and attenuated in time behavior (temporal control). Specific absorption rate for 470 kHz alternating magnetic field hyperthermia was 180 W/g.Flow cytometry with PI staining demonstrated 60% cell death with 15 min of 808 nm NIR laser exposure at 0.3 kW of laser power and 30 µg/ml of nanoparticles concentration. High magnetic saturation is prerequisite for potential magnetic targeting (special control), the size is within the range of EPR mediated accumulation. Summarizing, above mentioned nanocomposite has 5 theranostic modalities, which is more than previous works and may be considered as good candidate for further in vivo studies as “all-in-one” agent.