| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Khutoryanskiy, Vitaliy V.
University of Reading
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (16/16 displayed)
- 2024Modification of selectively acid-etched halloysite by mucoadhesive chitosan derivatives: new bionanocomposites with improved functional propertiescitations
- 2023Preparation of mucoadhesive methacrylated chitosan nanoparticles for delivery of ciprofloxacincitations
- 2023Ophthalmic drug delivery system based on the complex of gellan and ofloxacincitations
- 2023Formation of supramolecular gels from host-guest interactions between PEGylated chitosan and α-cyclodextrincitations
- 2022Understanding the temperature induced aggregation of silica nanoparticles decorated with temperature-responsive polymers: can a small step in the chemical structure make a giant leap for a phase transition?
- 2022Investigation of the Thermogelation of a Promising Biocompatible ABC Triblock Terpolymer and Its Comparison with Pluronic F127citations
- 2022Investigation of the thermogelation of a promising biocompatible ABC triblock terpolymer and its comparison with pluronic F127citations
- 2022Synthesis and evaluation of poly(3-hydroxypropyl ethylene-imine) and its blends with chitosan forming novel elastic films for delivery of haloperidolcitations
- 2022Ophthalmic drug delivery system based on the complex of gellan and ofloxacincitations
- 2021Understanding the temperature induced aggregation of silica nanoparticles decorated with temperature-responsive polymers: can a small step in the chemical structure make a giant leap for a phase transition?citations
- 2021Understanding the temperature induced aggregation of silica nanoparticles decorated with temperature-responsive polymers: Can a small step in the chemical structure make a giant leap for a phase transition?citations
- 2018Supramolecular hybrid structures and gels from host–guest interactions between α-cyclodextrin and PEGylated organosilica nanoparticlescitations
- 2017Enhancement and inhibition effects on the corneal permeability of timolol maleate: Polymers, cyclodextrins and chelating agentscitations
- 2016Evaluating and optimizing oral formulations of live bacterial vaccines using a gastro-small intestine modelcitations
- 2016Evaluating and optimizing oral formulations of live bacterial vaccines using a gastro-small intestine modelcitations
- 2014A laminated polymer film formulation for enteric delivery of live vaccine and probiotic bacteriacitations
Places of action
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article
Modification of selectively acid-etched halloysite by mucoadhesive chitosan derivatives: new bionanocomposites with improved functional properties
Abstract
In this study, the modification of selectively acid-etched halloysite (eHal) by low molecular weight chitosan (LChi) and its methacrylated derivative (MeLChi) is investigated to form new bionanocomposites with improved functional properties. The formation of nanocomposites was confirmed by various instrumental techniques (ζ-potential measurements, SEM, FT-IR, DSC, XRD and 1H NMR). Both nanocomposites exhibited improved functional properties while preserving the tubular structure of halloysite. The cytotoxic activity of eHal and eHal-polycation nanocomposites against normal human lung fibroblasts (MRC5) was determined using MTT assay. The results showed good biocompatibility of the prepared nanocomposites, with a cell survival rate of more than 90 %. The mucoadhesive properties of eHal and the corresponding chitosan nanocomposites were investigated in vitro. Primarily, ζ-potential measurements revealed electrostatic interactions between the eHal-polycation nanocomposites and mucin. The absorption study showed that the eHal-MeLChi nanocomposites could adsorb a greater amount of mucin (≈82 %) than the eHal-LChi nanocomposites (≈72 %) and eHal (≈58 %) after 8 h of incubation. Furthermore, the compacts of the tested samples were prepared by direct compression, and the detachment force against the mucin compact was measured using a texture analyzer. A significantly higher detachment force of the eHal-MeLChi nanocomposite compact (1.59 ± 0.07 N) from the mucin compact was determined compared to the eHal-LChi (1.35 ± 0.08 N) and eHal (0.98 ± 0.08 N) samples, demonstrating their improved mucoadhesive potential. In summary, this study demonstrates that functionalization of eHal with MeLChi may be a useful approach for the preparation of nanocomposites as potential carriers for mucoadhesive dosage forms.