• Lv, H.
• Liu, Wei
• He, J.
• Hw, Wang
• Tb, Wang
• Wc, Cao
• Yh, Luan
• Zy, Cao
• Xm, Wu
• Qm, Zhao
• Tang, F.
• Ph, Zhang

Abstract

<h4>Objective</h4>To investigate the association between the genetic polymorphisms of myxovirus resistance 1 (MxA) gene and susceptibility to severe acute respiratory syndromes (SARS).<h4>Methods</h4>A case-control study was conducted and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect the T/G polymorphism at position-88 in the mxA gene promoter. Information on related factors of SARS was collected using a pre-testing questionnaire. Univariate and multivariate logistic analyses were conducted with SPSS software package.<h4>Results</h4>Sixty-six cases and sixty-four controls were selected for the study. Comparing with GG genotype, the proportion of GT genotype were significantly higher in the case group (81.3%) than that in the control group (62.5%)) with an OR (95% CI) of 2.700 (1.208-6.037). Multivariate logistic regression analysis revealed that the significant association remained after factors as wearing masks, protection gowns and eye-protection when contacting with SARS patient etc. were adjusted with an OR (95 % CI) of 2.911 (1.027-8.250).<h4>Conclusion</h4>mxA promoter-88G/T SNP might be confered to host genetic susceptibility to SARS in Chinese Han population.

Topics

• susceptibility
• chemical ionisation