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Naji, M. |
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Motta, Antonella |
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Aletan, Dirar |
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Mohamed, Tarek |
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Ertürk, Emre |
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Taccardi, Nicola |
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Kononenko, Denys |
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Petrov, R. H. | Madrid |
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Alshaaer, Mazen | Brussels |
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Bih, L. |
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Casati, R. |
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Muller, Hermance |
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Kočí, Jan | Prague |
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Šuljagić, Marija |
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Kalteremidou, Kalliopi-Artemi | Brussels |
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Azam, Siraj |
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Ospanova, Alyiya |
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Blanpain, Bart |
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Ali, M. A. |
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Popa, V. |
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Rančić, M. |
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Ollier, Nadège |
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Azevedo, Nuno Monteiro |
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Landes, Michael |
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Rignanese, Gian-Marco |
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Chen, K.
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (26/26 displayed)
- 2022Kirigami inspired shape programmable and reconfigurable multifunctional nanocomposites for 3D structurescitations
- 2022Measurement of poly-Si film thickness on textured surfaces by X-ray diffraction in poly-Si/SiOx passivating contacts for monocrystalline Si solar cellscitations
- 2021Al-driven peculiarities of local coordination and magnetic properties in single-phase Alx-CrFeCoNi high-entropy alloyscitations
- 2021Polymer-Derived Silicon Nitride Aerogels as Shape Stabilizers for Low and High-Temperature Thermal Energy Storagecitations
- 2020Observation of compact ferrimagnetic skyrmions in DyCo3 filmcitations
- 2020Interfacial reaction between ZrNbHfTa foil and graphite: Formation of high-entropy carbide and the effect of heating rate on its microstructurecitations
- 2019Anisotropy and Enhancement of Thermoelectric Performance of Sr0.8La0.067Ti0.8Nb0.2O3- δ Ceramics by Graphene Additionscitations
- 2019Inter-ligand energy transfer in dye chromophores attached to high bandgap SiO<inf>2</inf> nanoparticlescitations
- 2018Enhancing the photoluminescence of surface anchored metal–organic frameworks: mixed linkers and efficient acceptorscitations
- 2018Direct Bandgap Behavior in Rashba-Type Metal Halide Perovskitescitations
- 2017Sintering trials of analogues of americium oxides for radioisotope power systemscitations
- 2017Vibronically coherent ultrafast triplet-pair formation and subsequent thermally activated dissociation control efficient endothermic singlet fissioncitations
- 2016Quantum size effects of small, size-selected and deposited CoRh clusters on Nicitations
- 2015Spark plasma sintered bismuth telluride-based thermoelectric materials incorporating dispersed boron carbidecitations
- 2015Observation of an atomic exchange bias effect in DyCo4 filmcitations
- 2012[Association between H-ras and L-myc gene polymorphisms and susceptibility to colorectal cancer].
- 2011Post-synthetic modification of epitaxially grown, highly oriented functionalized MOF thin filmscitations
- 2009[Association between HRE-2 gene polymorphism at codon 655 and genetic susceptibility of colorectal cancer].citations
- 2008[Application of multifactor dimensionality reduction on the interactions between gene-gene, gene-environment and the risk sporadic colorectal cancer in Chinese population].
- 2006[Association of single nucleotide polymorphisms and haplotypes in DNA repair gene XRCC1 with susceptibility of breast cancer].citations
- 2005Direct nitridation of molten Al(Mg,Si) alloy to AlNcitations
- 2005Migration of liquid phase in low temperature sintering of AlNcitations
- 2002Influence of the deagglomeration procedure on aqueous dispersion, slip casting and sintering of Si3N4-based ceramicscitations
- 2002A novel processing route for fabricating one-dimension elongated ca α-SiAlON crystalline powders
- 2002Combustion synthesis of Y α-SiALON whiskers
- 2001Influence of powder pre-treatments on dispersion ability of aqueous silicon nitride-based suspensionscitations
Places of action
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article
[Application of multifactor dimensionality reduction on the interactions between gene-gene, gene-environment and the risk sporadic colorectal cancer in Chinese population].
Abstract
<h4>Objective</h4>To identify the association between risk of sporadic colorectal cancer and the common single nucleotide polymorphisms (SNPs) in DNA repairs genes, gene to gene interactions among them and their gene to environment interactions with common environmental factors.<h4>Methods</h4>In this population-based case-control study, 206 primary colorectal cancer cases and 845 cancer-free healthy controls were enrolled. Genotyping was carried out using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique, with the status of subjects case or controls unknown. Multifactor dimensionality reduction (MDR) and logistic analysis were both used for association analysis.<h4>Results</h4>As compared to the younger age group (> or = 42, < 61 years), the risk of colorectal cancer in older age group (> or = 61 years) increased significantly (OR = 2.04, 95% CI: 1.49-2.80). Similar result was observed in the family cancer history (OR = 1.51, 95% CI: 1.05-2.17). However, no significant association between any single DNA repair gene SNP and colorectal cancer risk was discovered. Results from MDR analysis only showed a significant interaction among the four following factors: age, alcohol drinking, XRCC1 Arg194Trp and OGG1 Ser326Cys (the cross-validation consistency = 10/10, the average testing accuracy = 0.616, P = 0.011). Using a logistic regression model, the "high-risk" individuals had a significantly elevated risk of colorectal cancer compared to those "low- risk" individuals classified by the above MDR model (OR = 2.72, 95% CI: 1.66-4.47).<h4>Conclusion</h4>The impact of polymorphisms in DNA repair genes on the risk of sporadic colorectal cancer exhibited a low-penetrance characteristics while the intricate interactions existing among them and with environmental factors.