• Sosnowski, Tomasz Robert
• Jabłczyńska, Katarzyna

Abstract

Background: Biodegradable polymer nanoparticles are good candidatesfor carriers in targeted and controlled drug delivery. However,due to poor aerosolization, nanopowders themselves cannot form theeffective formulations for inhalations accomplished with DPIs.Therefore, it is desirable to prepare micrometer-sized nanostructuredpowders which could be easily dispersed to achieve high lung depositionon inhalation.Methods: Polymeric nanoparticles (150 – 30 nm) of polyaldehydedextran and dialdehyde carboxymethylcellulose were synthesized bywater-based methods. Aqueous nanosuspensions were used as precursorsin production of powders by spray-drying. Dry particles werecharacterized by SEM and their size distribution after aerosolizationin the DPI was determined by laser diffraction. In addition, trialson the restoration of the functional nanostructures by powder rehydrationwere undertaken.Results: Obtained powders had grain size of 0.5–5 lm and theydiffered in surface morphology depending on drying conditions.Aerosol particle median size was 1–2 lm and the FPF was alwaysabove 80%. Re-hydrated powders reconstituted the nanostructureswith the original particle size.Conclusions: Nanosuspensions of the selected biodegrable polymerscan be spray-dried to obtain respirable powders characterizedby a very good aerosolization properties, so they may beregarded as potential carriers of nanodrugs in pulmonary drug delivery.Acknowledgment: Work supported by NCN grant 2014/13/B/ST8/00808.

Topics

• nanoparticle
• impedance spectroscopy
• surface
• polymer
• grain
• grain size
• scanning electron microscopy
• drying