| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Kumar, Sumit
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (13/13 displayed)
- 2024Corrosion characteristics of 316L stainless steel in oxide-rich molten solar salt at 600 Ccitations
- 2024Influence of atmosphere and austenitic stainless steel on the solar salt corrosivity
- 2024Influence of precursor morphology and cathode processing on performance and cycle life of sodium-zinc chloride (Na-ZnCl 2 ) battery cellscitations
- 2023A resistance-driven H2 gas sensor: high-entropy alloy nanoparticles decorated 2D MoS2citations
- 2023Crystal phase selection in semiconductor nanowires
- 2022MOCVD growth and structural properties of ZnS nanowires: a case study of polytypismcitations
- 2022Observation of Quantum Griffith's singularity and anomalous metal in LaScO<SUB>3</SUB>/SrTiO<SUB>3</SUB> heterostructure
- 2022Growth and characterization of ZnS nanowires : highlights of polytypism ; Croissance et caractérisation de nanofils ZnS : étude du polytypisme
- 2022Temperature dependent cloaking of the Quantum Griffiths Singularity in LaScO$_3$/SrTiO$_3$ heterostructures
- 2022Induced structural modifications in ZnS nanowires via physical state of catalyst: Highlights of 15R crystal phasecitations
- 2022Thermal Energy Storage using Solar Salt at 620 °C: How a reactive gas atmosphere mitigates corrosion of structural materials
- 2021The Wnt-specific astacin proteinase HAS-7 restricts head organizer formation in Hydra
- 2019Observations on Thermal Coupling of Silicon Oscillators in Cryogen-Free Dilution Refrigeratorscitations
Places of action
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article
The Wnt-specific astacin proteinase HAS-7 restricts head organizer formation in Hydra
Abstract
<jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>The <jats:italic>Hydra</jats:italic> head organizer acts as a signaling center that initiates and maintains the primary body axis in steady state polyps and during budding or regeneration. Wnt/beta-Catenin signaling functions as a primary cue controlling this process, but how Wnt ligand activity is locally restricted at the protein level is poorly understood. Here we report a proteomic analysis of <jats:italic>Hydra</jats:italic> head tissue leading to the identification of an astacin family proteinase as a Wnt processing factor.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p><jats:italic>Hydra</jats:italic> astacin-7 (HAS-7) is expressed from gland cells as an apical-distal gradient in the body column, peaking close beneath the tentacle zone. <jats:italic>HAS-7</jats:italic> siRNA knockdown abrogates HyWnt3 proteolysis in the head tissue and induces a robust double axis phenotype, which is rescued by simultaneous <jats:italic>HyWnt3</jats:italic> knockdown. Accordingly, double axes are also observed in conditions of increased Wnt activity as in transgenic actin::HyWnt3 and <jats:italic>HyDkk1/2/4</jats:italic> siRNA treated animals. HyWnt3-induced double axes in <jats:italic>Xenopus</jats:italic> embryos could be rescued by coinjection of <jats:italic>HAS-7</jats:italic> mRNA. Mathematical modelling combined with experimental promotor analysis indicate an indirect regulation of <jats:italic>HAS-7</jats:italic> by beta-Catenin, expanding the classical Turing-type activator-inhibitor model.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>We show the astacin family protease HAS-7 maintains a single head organizer through proteolysis of HyWnt3. Our data suggest a negative regulatory function of Wnt processing astacin proteinases in the global patterning of the oral-aboral axis in <jats:italic>Hydra</jats:italic>.</jats:p></jats:sec>