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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Zhou, Jie
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (31/31 displayed)
- 2024Biodegradation-affected fatigue behavior of extrusion-based additively manufactured porous iron–manganese scaffoldscitations
- 2023Biomechanical evaluation of additively manufactured patient-specific mandibular cage implants designed with a semi-automated workflowcitations
- 2023Extrusion-based 3D printing of biodegradable, osteogenic, paramagnetic, and porous FeMn-akermanite bone substitutescitations
- 2023Quality of AM implants in biomedical applicationcitations
- 2022Extrusion-based additive manufacturing of Mg-Zn alloy scaffoldscitations
- 2022Additive manufacturing of bioactive and biodegradable porous iron-akermanite composites for bone regenerationcitations
- 2022Poly(2-ethyl-2-oxazoline) coating of additively manufactured biodegradable porous ironcitations
- 2022Additive Manufacturing of Biomaterialscitations
- 2021Extrusion-based 3D printing of ex situ-alloyed highly biodegradable MRI-friendly porous iron-manganese scaffoldscitations
- 2021Additively Manufactured Biodegradable Porous Zinc Implants for Orthopeadic Applications
- 2021Extrusion-based 3D printed biodegradable porous ironcitations
- 2021Biocompatibility and Absorption Behavior in Vitro of Direct Printed Porous Iron Porous Implants
- 2021Lattice structures made by laser powder bed fusioncitations
- 2020Additively manufactured biodegradable porous zinccitations
- 2020Multi-material additive manufacturing technologies for Ti-, Mg-, and Fe-based biomaterials for bone substitutioncitations
- 2019Additively manufactured functionally graded biodegradable porous ironcitations
- 2019Modeling high temperature deformation characteristics of AA7020 aluminum alloy using substructure-based constitutive equations and mesh-free approximation methodcitations
- 2019Biodegradation-affected fatigue behavior of additively manufactured porous magnesiumcitations
- 2018Additively manufactured biodegradable porous ironcitations
- 2018A comprehensive investigation of the strengthening effects of dislocations, texture and low and high angle grain boundaries in ultrafine grained AA6063 aluminum alloycitations
- 2018Biodegradation and mechanical behavior of an advanced bioceramic-containing Mg matrix composite synthesized through in-situ solid-state oxidationcitations
- 2017Advanced bredigite-containing magnesium-matrix composites for biodegradable bone implant applicationscitations
- 2017Improvement of mechanical properties of AA6063 aluminum alloy after equal channel angular pressing by applying a two-stage solution treatmentcitations
- 2017Additively manufactured biodegradable porous magnesiumcitations
- 2017Fabrication of novel magnesium-matrix composites and their mechanical properties prior to and during in vitro degradationcitations
- 2016Simultaneous improvements of the strength and ductility of fine-grained AA6063 alloy with increasing number of ECAP passescitations
- 2016An investigation on the properties of injection-molded pure iron potentially for biodegradable stent applicationcitations
- 2015Analysis of the densification behaviour of titanium/carbamide powder mixtures in the preparation of biomedical titanium scaffolds.
- 2015In vitro degradation of magnesium metal matrix composites containing bredigite
- 2015Evolution of macro- and micro-pores in the porous structures of biomedical titanium scaffolds during isothermal sintering
- 2010Preliminary investigation on creep-fatigue regime in extrusion dies
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document
Additively Manufactured Biodegradable Porous Zinc Implants for Orthopeadic Applications
Abstract
As compared to magnesium (Mg) and iron (Fe), solid zinc (Zn)-based absorbable implants show better degradation rates. An ideal bone substitute should provide sufficient mechanical support, but pure Zn itself is not strong enough for load-bearing medical applications. Modern processing techniques, like additive manufacturing (AM), can improve mechanical strength of Zn. To better mimic the in vivo situation in the human body, we evaluated the degradation behavior of porous Zn implants in vitro under dynamic conditions. Our study applied selective laser melting (SLM) to build topographically ordered absorbable Zn implants with superior mechanical properties. Specimens were fabricated from pure Zn powder using SLM and diamond unit cell topological design. In vitro degradation was performed under both static and dynamic conditions in a custom-built set-up under cell culture conditions (37 °C, 20% O2 and 5% CO2) for up to 28 days. Mechanical properties of the porous structures were determined according to ISO 13314: 2011 at different immersion time points. Modified ISO 10993 standards were used to evaluate biocompatibility through direct cell seeding and indirect extract-based cytotoxicity tests (MTS assay, Promega) against identically designed porous titanium (Ti-6Al-4V) specimens as reference material. Twenty-four hours after cell seeding, its efficacy was evaluated by Live-Dead staining (Abcam) and further analyzed using dual channel fluorescent optical imaging (FOI) and subsequent flow cytometric quantification. Porous Zn implants were successfully produced by means of SLM with a yield strength and Young's modulus in the range of 3.9–9.6 MPa and 265–570 MPa, respectively. Dynamic flow significantly increased the degradation rate of AM porous Zn after 28 days. Results from Zn extracts were similar to Ti-6Al-4V with >95% of cellular activity at all tested time points, confirming level 0 cytotoxicity (i.e., This study clearly shows the great potential of AM porous Zn as a bone substituting material. Moreover, we demonstrate that complex topological design permits control of mechanical properties and degradation behavior.