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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Drechsler, Markus
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (7/7 displayed)
- 2022Manganese in Diagnostics: A Preformulatory Studycitations
- 2019Pep-Lipid Cubosomes and Vesicles Compartmentalized by Micelles from Self-Assembly of Multiple Neuroprotective Building Blocks Including a Large Peptide Hormone PACAP-DHA
- 2018Stabilization of Mineral Precursors by Intrinsically Disordered Proteinscitations
- 2017Magneto-Adaptive Surfactants Showing Anti-Curie Behavior and Tunable Surface Tension as Porogens for Mesoporous Particles with 12-Fold Symmetrycitations
- 2012Preparation and characterization of ellipsoidal-shaped thermosensitive microgel colloids with tailored aspect ratioscitations
- 2012Direct synthesis of inverse hexagonally ordered diblock copolymer/polyoxometalate nanocomposite filmscitations
- 2005"Smart" silica-rubber nanocomposites in virtue of hydrogen bonding interactioncitations
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article
Pep-Lipid Cubosomes and Vesicles Compartmentalized by Micelles from Self-Assembly of Multiple Neuroprotective Building Blocks Including a Large Peptide Hormone PACAP-DHA
Abstract
Structural control over design and formation of selfassembled nanomaterials for neuroprotection and neuroregeneration is crucial for their application in nanomedicine. Here a synthetic construct of the pituitary adenylate cyclase-activating polypeptide (PACAP38) coupled to a docosahexaenoic acid (DHA: an ω-3 polyunsaturated fatty acid (PUFA)) is designed towards the creation of compartmentalized liquid crystalline assemblies of neuroprotective compounds. The hormone PACAP38 is a ligand of the class B PAC1 G-protein-coupled receptor (GPCR), whereas DHA is a lipid trophic factor. The lipidated peptide PACAP-DHA is co-assembled into hierarchical nanostructures elaborated from hybrid vesicle-micelle reservoirs as well into PEGylated cubosomes composed of multiple neuroprotective building blocks. The resulting nanostructures are determined by synchrotron small-angle X-ray scattering (BioSAXS) and cryogenic transmission electron microscopy (cryo-TEM). Multicompartment topologies are obtained in a twofold approach: (i) intriguing compartmentalized vesicles, which embed pep-lipid micelles forming nanopatterns, and (ii) multidomain pep-lipid cubosomes. Both kinds of topologies are favorable for sustainedrelease applications in combination therapies of neurodegeneration. The organizational complexity of the scaffolds involving the lipidated high-molecular weight peptide hormone is beyond the one that has been reached with small lipid-like peptide surfactants.