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Naji, M. |
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Motta, Antonella |
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Aletan, Dirar |
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Mohamed, Tarek |
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Ertürk, Emre |
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Taccardi, Nicola |
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Kononenko, Denys |
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Petrov, R. H. | Madrid |
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Alshaaer, Mazen | Brussels |
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Bih, L. |
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Casati, R. |
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Muller, Hermance |
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Kočí, Jan | Prague |
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Šuljagić, Marija |
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Kalteremidou, Kalliopi-Artemi | Brussels |
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Azam, Siraj |
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Ospanova, Alyiya |
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Blanpain, Bart |
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Ali, M. A. |
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Popa, V. |
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Rančić, M. |
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Ollier, Nadège |
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Azevedo, Nuno Monteiro |
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Landes, Michael |
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Rignanese, Gian-Marco |
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Kumar, Pradeep
in Cooperation with on an Cooperation-Score of 37%
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Publications (8/8 displayed)
- 2024A flexible dual-band 4 × 4 MIMO antenna for 5G mm-wave 28/38 GHz wearable applicationscitations
- 2024Numerical crashworthiness analysis of 2014 Aluminium- Silicon Carbide Particle (SiCp) foam filled Carbon Fiber-Reinforced Plastic (CFRP) tube under impact loading
- 2024The interplay of topology and antiferromagnetic order in two-dimensional van der Waals crystals of (NixFe1-x)2P2S6citations
- 2023Investigations on effect of pore architectures of additively manufactured novel hydroxyapatite coated PLA/Al<sub>2</sub>O<sub>3</sub> composite scaffold for bone tissue engineering
- 2023Physicochemical investigations of nanoemulsified, curcumin-loaded, crosslinked κ-carrageenan hydrogels
- 2016Analog switching in the nanocolloids of ferroelectric liquid crystalscitations
- 2014An interfacially plasticized electro-responsive hydrogel for transdermal electro-activated and modulated (TEAM) drug delivery
- 2014An interfacially plasticized electro-responsive hydrogel for transdermal electro-activated and modulated (TEAM) drug deliverycitations
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article
Investigations on effect of pore architectures of additively manufactured novel hydroxyapatite coated PLA/Al<sub>2</sub>O<sub>3</sub> composite scaffold for bone tissue engineering
Abstract
<jats:sec> <jats:title content-type="abstract-subheading">Purpose</jats:title> <jats:p>The purpose of this paper is to fabricate the scaffolds with different pore architectures using additive manufacturing and analyze its mechanical and biological properties for bone tissue engineering applications.</jats:p> </jats:sec> <jats:sec> <jats:title content-type="abstract-subheading">Design/methodology/approach</jats:title> <jats:p>The polylactic acid (PLA)/composite filament were fabricated through single screw extrusion and scaffolds were printed with four different pore architectures, i.e. circle, square, triangle and parallelogram with fused deposition modelling. Afterwards, scaffolds were coated with hydroxyapatite (HA) using dip coating technique. Various physical and thermo-mechanical tests have been conducted to confirm the feasibility. Furthermore, the biological tests were conducted with MG63 fibroblast cell lines to investigate the biocompatibility of the developed scaffolds.</jats:p> </jats:sec> <jats:sec> <jats:title content-type="abstract-subheading">Findings</jats:title> <jats:p>The scaffolds were successfully printed with different pore architectures. The pore size of the scaffolds was found to be nearly 1,500 µm, and porosity varied between 53% and 63%. The fabricated circular pore architecture resulted in highest average compression strength of 13.7 MPa and modulus of 525 MPa. The characterizations showed the fidelity of the work. After seven days of cell culture, it was observed that the developed composites were non-toxic and supported cellular activities. The coating of HA made the scaffolds bioactive, showing higher wettability, degradation and high cellular responses.</jats:p> </jats:sec> <jats:sec> <jats:title content-type="abstract-subheading">Originality/value</jats:title> <jats:p>The research attempts highlight the development of novel biodegradable and biocompatible polymer (PLA)/bioactive ceramic (Al<jats:sub>2</jats:sub>O<jats:sub>3</jats:sub>) composite for additive manufacturing with application in the tissue engineering field.</jats:p> </jats:sec>