• Karmaus, A.
• Hines, David Earl
• Kleinstreuer, N.
• Mcafee, Eric
• Casey, W.
• Chang, X.
• Cook, Bethany Therese
• Phillips, J.
• Allen, David
• Rooney, John

Abstract

New approach methodologies (NAMs) are generally defined as non-animal methods or<br/>approaches using one or more in vitro or in silico methods to provide insight on chemical hazard.<br/>While scientific and policy advances have enabled adoption of some NAMs for specific<br/>applications, barriers remain to broader acceptance of NAMs for regulatory purposes, where<br/>animal-based testing paradigms remain the standard. The National Toxicology Program’s<br/>Integrated Chemical Environment (ICE) addresses these barriers to build confidence in NAMs.<br/>ICE provides access to high-quality, curated, regulatory-relevant data and in silico predictions of<br/>chemical properties. ICE computational tools allow users to search for, visualize, and obtain<br/>context for these data. ICE data acquisition and curation processes are transparent and include<br/>citations to original data sources. Efforts are underway to apply controlled vocabularies during<br/>curation to increase interoperability of data. High-throughput screening assays from the ToxCast<br/>and Tox21 programs have been annotated to mechanistic targets and modes of action to provide<br/>biological context for assay results. Curated data from these assays can easily be viewed in<br/>concentration-response format using the Curve Surfer tool. Other computational tools available<br/>in ICE allow users to run physiologically based pharmacokinetics and in vitro to in vivo<br/>extrapolation models and to search for structurally similar chemicals. These tools are designed to<br/>be accessed by diverse end-users through simple user interfaces. This project was funded with<br/>federal funds from the NIEHS, NIH under Contract No. HHSN273201500010C.

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