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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Ali, M. A. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Rignanese, Gian-Marco |
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Ignjatović, Nenad
Serbian Academy of Sciences and Arts
in Cooperation with on an Cooperation-Score of 37%
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Publications (5/5 displayed)
- 2023Antimicrobial and Osteogenic Effects of Collagen Membrane Decorated with Chitosan–Nano-Hydroxyapatitecitations
- 2022Hydroxyapatite grafting with alanine amino acid - efficiency of different methods
- 2018Selective anticancer activity of hydroxyapatite/chitosan-poly(D,L)-lactide-co-glycolide particles loaded with an androstane-based cancer inhibitorcitations
- 2018Selective anticancer activity of hydroxyapatite/chitosan-poly(D,L)-lactide-co-glycolide particles loaded with an androstane-based cancer inhibitorcitations
- 2018Cell-selective toxicity of hydroxyapatite-chitosan oligosaccharide lactate particles loaded with a steroid cancer inhibitor
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document
Hydroxyapatite grafting with alanine amino acid - efficiency of different methods
Abstract
Hydroxyapatite (HAp) attracts great attention due to application in reconstructive medicine for hard tissues, mostly bones and teeth, where it is declared to be highly biocompatible material. Its grafting with amino acids further increases biocompatibility and has crucial importance for acceptance of body implants. In this work different methods of grafting were investigated: simple mixing, thermal treatment induction and in situ synthesis/grafting reactions. Two amino acid precursors were separately tested in grafting procedures: pure alanine and alanine methyl ester hydrochloride. The efficiency of grafting was determined based on X-ray powder diffraction (XRPD), Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and thermal analyses (DSC, TG/DTA) of obtained powders, while complementary UV-VIS spectroscopy of supernatants was additionally performed for quantitative determination of non-grafted nitrogen using ninhydrin standardized procedure.