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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Wilkinson, James
University of Southampton
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (34/34 displayed)
- 2022Study of prediction intervals in machine learning assisted mid-infrared spectroscopy for the diagnosis of neonatal respiratory distress syndrome
- 2022Prediction of neonatal respiratory distress biomarker concentration by application of machine learning to mid-infrared spectracitations
- 2021High-bandwidth InGaAs photodetectors heterogeneously integrated on silicon waveguides using optofluidic assemblycitations
- 2021The Effect of Haematocrit on Measurement of the Mid-Infrared Refractive Index of Plasma in Whole Bloodcitations
- 2019Mid-IR thermo-optic on-chip spectrometer on a III-V semiconductor platform
- 2018Tantalum pentoxide waveguides and microresonators for VECSEL based frequency combscitations
- 2018Chalcogenide glass waveguides with paper-based fluidics for mid-infrared absorption spectroscopycitations
- 2017Optical quality ZnSe films and low loss waveguides on Si substrates for mid-infrared applicationscitations
- 2015Wavelength division demultiplexer and integrated III-V semiconductor Lasers on a silicon photonics platform with microbubble manipulation
- 2014High-contrast, GeTe4 waveguides for mid-infrared biomedical sensing applicationscitations
- 2012Structural characteristics and optical properties of plasma assisted reactive magnetron sputtered dielectric thin films for planar waveguiding applicationscitations
- 2012Kinoform microlenses for focusing into microfluidic channelscitations
- 2011Integrated Nd-doped borosilicate glass microsphere lasercitations
- 2011Chalcogenide microsphere fabricated from fibre taper-drawn using resistive heating
- 2011Lead silicate glass microsphere resonators with absorption-limited Qcitations
- 2010Simultaneous poling and planar waveguide fabrication in glasses
- 2010Position-dependent coupling between a channel waveguide and a distorted microsphere resonatorcitations
- 2010Structural and optical properties of yttrium oxide thin films for planar waveguiding applicationscitations
- 2010Chalcogenide glass microsphere lasercitations
- 2009Chalcogenide glass microspheres and their applications
- 2009Optical fiber nanowires and microwires: fabrication and applicationscitations
- 2007Chalcogenide glass microspheres: their production characterization and potentialcitations
- 2006Whispering gallery modes excitation in borosilicate glass microspheres by K+ ion-exchanged channel waveguide couplercitations
- 2006Control of coupling between waveguides and microsphere resonators
- 2005Strong refractive index changes induced in Ag ion exchanged Er doped phosphate glass using 248 nm excimer laser radiation
- 2004Strong refractive index changes induced in Ag+ ion-exchanged Er-doped phosphate glass using 248nm excimer laser radiation
- 2004Long refractive index changes induced in Ag+ ion-exchanged Er-doped phosphate glass using 248nm excimer laser radiation
- 2004Photosensitivity of ion-exchanged Er-doped phosphate glass using 248nm excimer laser radiationcitations
- 2003Sub-micron period grating structures in Ta2O5 thin oxide films patterned using UV laser post-exposure chemically assisted selective etching
- 2003New deep glass etching technology
- 2002Planar waveguides in multicomponent glasses fabricated by field-driven differential drift of cationscitations
- 2001Gratings in indium oxide film overlayers on ion-exchanged waveguides by excimer laser micromachiningcitations
- 2001Dynamic AC surface discharge characteristics of PMMA and LDPEcitations
- 2000Relief gratings on Er/Yb-doped borosilicate glasses and waveguides by excimer laser ablationcitations
Places of action
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document
Study of prediction intervals in machine learning assisted mid-infrared spectroscopy for the diagnosis of neonatal respiratory distress syndrome
Abstract
Point of care devices present an attractive proposition for a rapid, evidenced based, diagnosis to be provided at the patient bedside, and give clinicians access to almost real-time information about a patient's condition.Devices based on attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) can provide rapid, label free measurements consistent with delivery of bedside care.Neonatal respiratory distress syndrome (nRDS) affects some pre-term neonates from their first breath and delays in treatment are associated with poor clinical outcomes.nRDS can be diagnosed by analysis of the lecithin/sphingomyelin ratio (L/S ratio) of the lung surfactant obtained from bronchoalveolar lavage.Following on from our work on mid-infrared spectroscopy for the diagnosis of nRDS, where we established a data processing methodology to evaluate machine learning algorithms used for determining L/S ratios of simple mixtures, this work develops the process, by increasing the number of constituents and using smaller calibration steps to more closely match the patient sample. We will show the performance of machine/deep learning algorithms to predict the concentrations of the constituents present and their L/S ratio along with prediction intervals indicating the uncertainty in the measurement.The results will further inform calibration procedures for a proof-of-principal ATR-FTIR based point-of-care device that can be used in a clinical setting to provide a rapid indication of the L/S ratio of patient samples.