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Naji, M. |
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Motta, Antonella |
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Aletan, Dirar |
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Mohamed, Tarek |
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Ertürk, Emre |
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Taccardi, Nicola |
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Kononenko, Denys |
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Petrov, R. H. | Madrid |
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Alshaaer, Mazen | Brussels |
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Bih, L. |
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Casati, R. |
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Muller, Hermance |
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Kočí, Jan | Prague |
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Šuljagić, Marija |
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Kalteremidou, Kalliopi-Artemi | Brussels |
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Azam, Siraj |
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Ospanova, Alyiya |
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Blanpain, Bart |
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Ali, M. A. |
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Popa, V. |
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Rančić, M. |
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Ollier, Nadège |
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Azevedo, Nuno Monteiro |
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Landes, Michael |
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Rignanese, Gian-Marco |
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Zhang, C.
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (18/18 displayed)
- 2024Organic Mixed Ionic Electronic Conductor Nanochannels for Vertical Electrochemical and Ionic Transistorscitations
- 2024Recrystallization kinetics in 3D printed 316L stainless steelcitations
- 2022Influence of photooxidation on ionic reversible interactions of ionic poly(ether urethane)/silica hybridscitations
- 2022Copolymerization of Carbonyl Sulfide and Propylene Oxide via a Heterogeneous Prussian Blue Analogue Catalyst with High Productivity and Selectivity.citations
- 2021The prismatic surface cell cooling coefficient: A novel cell design optimisation tool & thermal parameterization method for a 3D discretised electro-thermal equivalent-circuit model
- 2020Particle-based simulation of cold spray: Influence of oxide layer on impact processcitations
- 2020The prismatic surface cell cooling coefficient: A novel cell design optimisation tool & thermal parameterization method for a 3D discretised electro-thermal equivalent-circuit modelcitations
- 2019Bioelectrochemical recovery of silver from wastewater with sustainable power generation and its reuse for biofouling mitigationcitations
- 2018Hot wire-assisted gas metal arc welding of Ni-based hardfacingcitations
- 2018Modelling fracture and delamination in composite laminates: Energy release rate and interfacial stresscitations
- 2018Meso-scale progressive damage modeling and life prediction of 3D braided composites under fatigue tension loading
- 2017Finite element analysis of the damage mechanism of 3D braided composites under high-velocity impactcitations
- 2017A novel interface constitutive model for prediction of stiffness and strength in 3D braided compositescitations
- 2016Overcoming the Thermal Instability of Efficient Polymer Solar Cells by Employing Novel Fullerene-Based Acceptorscitations
- 2015A Multitechnique Study of CO Adsorption on the TiO<inf>2</inf> Anatase (101) Surfacecitations
- 2014Grain boundaries and interfaces in slip transfercitations
- 2012[Promoting of angiogenesis and osteogenesis in radial critical bone defect regions of rabbits with nano-hydroxyapatite/collagen/PLA scaffolds plus endothelial progenitor cells].
- 2011In-situ study of growth of carbon nanotube forests on conductive CoSi2 supportcitations
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article
[Promoting of angiogenesis and osteogenesis in radial critical bone defect regions of rabbits with nano-hydroxyapatite/collagen/PLA scaffolds plus endothelial progenitor cells].
Abstract
<h4>Objective</h4>To explore the roles of nano-hydroxyapatite/collagen/PLA (nHAC/PLA) plus endothelial progenitor cells (EPCs) in repairing segmental bone defects of rabbit radius and enhancing angiogenesis and new bone formation.<h4>Methods</h4>EPCs isolated from New Zealand white rabbit bone marrow were cultured, identified and seeded into nHAC/PLA scaffolds. And the growth of EPCs in scaffolds was observed under scanning electron microscopy (SEM). Thirty-six were randomly divided into 3 groups to establish segmental bone defect models in radii. Two groups were implanted with EPCs/scaffolds constructs (group A, n = 16) and scaffolds alone (group B, n = 16) respectively. The remaining four rabbits were used as negative control (group C) and nothing was implanted. Animals were sacrificed at different timepoints and radii harvested to undergo radiological examination, histological examination and microvessle density test.<h4>Results</h4>These cells isolated from bone marrow were confirmed as EPCs. SEM showed that EPCs attached to the nHAC/PLA scaffolds, grew and proliferated well. Animal experiments revealed that radiological scores (5w: 2.25 ± 0.50 vs 1.00 ± 0.00; 10w: 2.75 ± 0.50 vs 1.75 ± 0.50; 15w: 4.25 ± 0.50 vs 3.0 ± 0.0; each P < 0.05), percentage of new bone formation area in bone defect regions (5w: 29.0% ± 3.5% vs 8.1% ± 0.8%; 10w: 63.4% ± 5.5% vs 16.6% ± 1.3%; 15w: 96.0% ± 4.3% vs 34.0% ± 6.6%; each P < 0.05) and microvessel density (2w: 13.5 ± 0.9 vs 4.3 ± 1.0; 5w:9.8 ± 0.7 vs 4.8 ± 0.3; 10w: 7.0 ± 0.4 vs 4.5 ± 0.4; each P < 0.05) in group A were significantly higher than those in group B. No new bone formation occurred in group C.<h4>Conclusion</h4>The composite structure of EPCs-nHAC/PLA can enhance angiogenesis and new bone formation in segmental bone defects in rabbit radii. It may become a potential candidate of promoting revascularization of tissue engineering bone and repairing large bone defects.