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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Palacin, Serge
Direction de la Recherche Technologique
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (26/26 displayed)
- 2017Hybrid metal-polymer nanoparticles as promising radiosensitizers for cancer treatment
- 2016Pulse potential deposition of thick polyvinylpyridine-like film on the surface of titanium nitridecitations
- 2014VUV grafting process: An efficient tool for 3D bulk patterning of polymer sheetscitations
- 2013A H2-evolving photocathode based on direct sensitization of MoS3 with an organic photovoltaic cellcitations
- 2013Polymer grafting by inkjet printing: a direct chemical writing toolsetcitations
- 2012Towards organic film passivation of germanium wafers using diazonium salts: mechanism and ambient stabilitycitations
- 2011Localized Ligand Induced Electroless Plating (LIEP) Process for the fabrication of copper patterns onto flexible polymer substratescitations
- 2011Polystyrene Tribological Performance: Progress in the Understanding of Polymers Attrition during Chemical Engineering Processes
- 20113D-amino-induced electroless plating process: a powerful toolset for localized metallization onto polymers substratescitations
- 2010Microscopic study of a ligand-induced electroless plating process onto polymerscitations
- 2010ABS Polymer Electroless Plating through a One-Step Poly(acrylic acid) Covalent Graftingcitations
- 2009Low-temperature growth of nano-structured silicon thin films on ITO initiated by metal catalysts
- 2009Electrochemical-switchable polymer film: an emerging technique for treatment of metal ion waste watercitations
- 2009Selective electroless copper deposition on self-assembled dithiol monolayerscitations
- 2009Electrochemical behavior of polyacrylic acid coated gold electrodes: an application to remove heavy metal ions from wastewatercitations
- 2009Surface Electroinitiated Emulsion Polymerization (SEEP): A mechanistic approachcitations
- 2009On the structure-property relationship of the AMV anion-exchange membranecitations
- 2008Conducting and lubricating nanocomposites thin films based on carbon nanotubes and fluorinated poly(methacrylate)
- 2008Grafting organic polymer films on surfaces of carbon nanotubes by surface electroinitiated emulsion polymerizationcitations
- 2008Investigation of the mechanical and electrical properties of nanocomposite thin films by conducting probe AFM
- 2007Hybrid solar cells based on thin-film silicon and P3HTcitations
- 2007Carbon nanotubes/fluorinated polymers nanocomposite thin films for electrical contacts lubricationcitations
- 2007Grafting Polymers on Surfaces: A New Powerful and Versatile Diazonium Salt-Based One-Step Process in Aqueous Mediacitations
- 2006New concept to remove heavy metals from liquid waste based on electrochemical ph-switchable immobilised ligands.citations
- 2006Tetrathiafulvalene-based podands bearing one or two thiol functions : Immobilization as self-assembled monolayers or polymer films, and recognition properties.citations
- 2006Carbon nanotubes/fluorinated polymers nanocomposite thin films for electrical contacts lubrication
Places of action
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document
Hybrid metal-polymer nanoparticles as promising radiosensitizers for cancer treatment
Abstract
Nanotechnologies are being widely studied for medical applications, both diagnosis and treatment. They have already shown great promise, especially to treat cancer through various strategies such as chemotherapy, photothermal therapy or radiation therapies. High-Z elements nanoparticles are of particular interest for the latter, considering their ability to amplify the damaging effects of both photon and ion radiations: gold, platinum and gadolinium are amongst the most investigated elements. A well-controlled synthesis is key to obtain stable and scalable nano-objects. Here, various polymers were grafted onto metallic nanoparticles to improve stability and biocompatibility and to facilitate subsequent functionalization. Advanced methods of characterization attested to the robustness and reproducibility of the synthesis procedure. Moreover, promising results were obtained regarding the radioenhancing properties of these hybrid nanocompounds. Polymers mainly synthesized via controlled radical polymerization were grafted onto gold and platinum nanoparticles by a "grafting to" or "grafting from" method. Subsequent grafting of a chemotherapy drug onto the polymer corona was also successfully carried out. The resulting nano-objects were fully characterized by thermogravimetric analysis, transmission electronic microscopy and small-angle x-ray scattering. Small-angle neutron scattering was also performed, taking advantage of possible contrast matching. The impact of various radiation doses on the nanoparticles structure was studied. Finally, radiosensitizing effects were investigated through in vitro tests. Under irradiation, uncoupling and cleavage of polymer chains were demonstrated, leading to an overall size reduction of the hybrid nano-objects. The location of target sites during irradiation was determined (see attached figure) and helped to better understand the underlying mechanism of the radiosensitization assessed by the in vitro results. The synthesized nano-objects have therefore shown great potential to enhance radiation cancer treatment. Their stability and controlled surface chemistry will allow to develop multiple strategies to further improve their radiosensitizing effect and in vitro behavior. In vivo tests are currently under study, as well as experiments regarding radioenhancement for proton therapy.