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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Fages, Jacques
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (19/19 displayed)
- 2023Foaming of PLA biocomposites by supercritical CO2 assisted extrusion process
- 2023Foaming of PLA biocomposites by supercritical CO2 assisted extrusion process
- 2021PLA-based biocomposites foaming by supercritical CO2 assisted batch process
- 2021PLA-based biocomposites foaming by supercritical CO2 assisted batch process
- 2021Blending and foaming thermoplastic starch with poly (lactic acid) by CO 2 ‐aided hot melt extrusioncitations
- 2021Foaming of PLA-based Biocomposites by Supercritical CO2 Assisted Batch Process : Effect of Processing and Cellulose Fibres on Foam Microstructure
- 2021Foaming of PLA-based Biocomposites by Supercritical CO2 Assisted Batch Process : Effect of Processing and Cellulose Fibres on Foam Microstructure
- 2017Modelling Nucleation and Cell Size During the Continuous Process of Extrusion Assisted by Supercritical CO 2
- 2016Characterisation of natural fibre reinforced PLA foams prepared by supercritical CO 2 assisted extrusioncitations
- 2012Use of supercritical CO2-aided and conventional melt extrusion for enhancing the dissolution rate of an active pharmaceutical ingredientcitations
- 2011On-line rheological measurement of a binary mixture polymer/sc-CO2 in an extruder
- 2011New challenges in polymer foaming: A review of extrusion processes assisted by supercritical carbon dioxidecitations
- 2010Biosourced polymer foam production using a (SC CO2) -assisted extrusion process
- 2008A new supercritical co-injection process to coat microparticlescitations
- 2008Application of the Markov chain theory for modelling residence time distribution in a single screw extruder
- 2007Microencapsulation by a solvent-free supercritical fluid process : use of density, calorimetric, and size analysis to quantify and qualify the coatingcitations
- 2004A new test for cleaning efficiency assessment of cleaners for hard surfacescitations
- 2004Supercritical carbon dioxide : an efficient tool for the production of ultra-fine particles for the food and pharmaceutical industries
- 2002Extraction and precipitation particle coating using supercritical CO2citations
Places of action
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conferencepaper
Supercritical carbon dioxide : an efficient tool for the production of ultra-fine particles for the food and pharmaceutical industries
Abstract
The agro-food, pharmaceutical, cosmetics and detergent industries are among the greatest users of particulate solids, or powders. It is hardly necessary, therefore, to expound their industrial importance. However, there is still plenty of room for development, as their generation, their formulation and the control of their usage properties are yet to be fully mastered. In the domain of particle formation, there are traditionally two main ways of obtaining divided solids, depending on whether the base material is in the solid or liquid state: crushing, milling, comminution belong to the former category while crystallisation, precipitation, spray-drying and atomization belong to the latter.Obtaining powders by processes using supercritical fluids is a third route, which has undergone significant development during the last decade. By using pressure as an operating parameter, these processes lead to the production of fine and monodisperse powders. There exist three families of processes (RESS, SAS and PGSS) according to the way in which the FSC - generally CO2 - is used. •In the RESS process, CO2 is the solvent and it is the fall of density related to a rapid depressurisation which promotes the nucleation of the solute. Although it is easy to implement, this process is however limited by the relatively tight spectrum of CO2-solvent properties.•In the SAS process, CO2 is used as a non (or anti)-solvent and it is the reciprocal dissolution of an organic solution and the supercritical fluid which causes precipitation. The great versatility of SAS remains its principal advantage.•Lastly, in the PGSS process, the dissolution of CO2 into an organic solution or a molten polymer, is followed by an abrupt depressurisation in which the dissolved gas acts as an aerosol generator helping the particle formation. This process is particularly advisable for polymer coating applications.In this paper, two examples of application of these processes are described. A high-value foodstuff, cocoa butter has been crystallised in a specific polymorph. The particles produced can be used to improve tempering, a key-stage in the chocolate manufacturing process.Secondly, a hypocholesterolemic drug, eflucimibe, has been processed. A new process using three different steps has allowed a significant improvement in dissolution rate and oral bioavailability.