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Shui, Lingling
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document
A lab-on-a-chip system integrated with subwavelength periodic patterned metal surfaces for sers-based molecular identification biosensing
Abstract
We present a new lab-on-a-chip (LOC) analysis platform that is integrated with nanotextured surfaces with periodically spaced subwavelength nanogroove and nanopyramid structures with precisely defined pitch λg and separation gaps of ~2 nm spacing that form high density arrays of hot-spot scattering sites ideally suited for surface enhanced Raman scattering (SERS) and Raman spectroscopy using small sample volumes. The simple fabrication technique requires conventional lithography, wet anisotropic etching and a bonded polymer microfluidic layer. Measured Raman enhancement factors of G~106 from rhodamine 6G (R6G) on patterned Au surfaces with λg=200 nm are consistent with numerical calculations.