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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Li, Wei
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (31/31 displayed)
- 2024Elucidating the Non-Covalent Interactions that Trigger Interdigitation in Lead-Halide Layered Hybrid Perovskites.citations
- 2024Elucidating the non-covalent interactions that trigger interdigitation in lead-halide layered hybrid perovskitescitations
- 2024Polycrystalline silicon, a molecular dynamics study : I. Deposition and growth modescitations
- 2024Polycrystalline silicon, a molecular dynamics study: Part I --- Deposition and growth modescitations
- 2024AM-SegNet for additive manufacturing in situ X-ray image segmentation and feature quantification
- 2024Efficient ab initio stacking fault energy mapping for dilute interstitial alloyscitations
- 2024Polycrystalline silicon, a molecular dynamics study: Part II --- Grains, grain boundaries and their structurecitations
- 2023Reconciling experimental and theoretical stacking fault energies in face-centered cubic materials with the experimental twinning stresscitations
- 2023Hard and tough novel high-pressure $γ-Si_3N_4/Hf_3N_4$ ceramic nanocompositescitations
- 2023Forecasting the Friction Coefficient of Rubbing Zirconia Ceramics by Titanium Alloycitations
- 2023Inferring mechanical properties of the SARS-CoV-2 virus particle with nano-indentation tests and numerical simulationscitations
- 2023Ab initio study of the effect of interstitial alloying on the intrinsic stacking fault energy of paramagnetic gamma-Fe and austenitic stainless steelcitations
- 2023Ab initio study of the effect of interstitial alloying on the intrinsic stacking fault energy of paramagnetic γ-Fe and austenitic stainless steelcitations
- 2022Single-source-precursor derived bulk Si3N4HfBxN(1-x) ceramic nanocomposites with excellent oxidation resistancecitations
- 2021An organic-inorganic hybrid scaffold with honeycomb-like structures enabled by one-step self-assembly-driven electrospinningcitations
- 2021An organic-inorganic hybrid scaffold with honeycomb-like structures enabled by one-step self-assembly-driven electrospinningcitations
- 2021Intracellular delivery of budesonide and polydopamine co-loaded in endosomolytic poly(butyl methacrylate-co-methacrylic acid) grafted acetalated dextran for macrophage phenotype switch from M1 to M2citations
- 2020In Situ N-Doped Graphene and Mo Nanoribbon Formation from Mo2Ti2C3 MXene Monolayers
- 2020Pompon Dahlia-like Cu2O/rGO Nanostructures for Visible Light Photocatalytic H2 Production and 4-Chlorophenol Degradationcitations
- 2020Intracellular co-delivery of melanin-like nanoparticle and budesonide by endosomolytic polymeric materials for anti-inflammatory therapy
- 2019Red-Shifted Absorptions of Cation-Defective and Surface-Functionalized Anatase with Enhanced Photoelectrochemical Propertiescitations
- 2017Picrasidine G decreases viability of MDA-MB 468 EGFR-overexpressing triple-negative breast cancer cells through inhibition of EGFR/STAT3 signaling pathway.citations
- 2017Decomposition of CoF3 during Battery Electrode Processing
- 2017Rubidium Multication Perovskite with Optimized Bandgap for Perovskite-Silicon Tandem with over 26% Efficiencycitations
- 2017Thermal expansion in FeCrCoNiGa high-entropy alloy from theory and experimentcitations
- 2016Enhancing the Optoelectronic Performance of Perovskite Solar Cells via a Textured CH3NH3PbI3 Morphologycitations
- 2016Enhancing the optoelectronic performance of perovskite solar cells via a textured CH3NH3PbI3 morphologycitations
- 2015Microfluidic chip designs process optimization and dimensional quality controlcitations
- 2015Elastic properties and acoustic dissipation associated with a disorder–order ferroelectric transition in a metal–organic frameworkcitations
- 2013Initial stage of free pressureless spark-plasma sintering of vanadium carbide: Determination of surface diffusion parameterscitations
- 2001Doping and carrier transport in Ga1−3xIn3xNxAs1−x alloyscitations
Places of action
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document
Intracellular co-delivery of melanin-like nanoparticle and budesonide by endosomolytic polymeric materials for anti-inflammatory therapy
Abstract
Introduction: Non-resolving inflammation drives the development of many prevalent chronic diseases, including rheumatoid arthritis, atherosclerosis, diabetes and some types of cancer. (1) Recent studies found that natural melanin nanoparticles (MNs) from Sepia ink had superior antioxidant potency due to the reactive oxygen species (ROS) scavenging capability. (2) Considering the prevalent oxidative stress closely associated with chronic non-resolving inflammation associated diseases. (3) MNs from Cephalopod ink, may show promising potential in anti-inflammatory applications. Although traditional MN preparation methods generate homogenous nanoparticles, the lengthy reaction times and unavoidable batch-to-batch variations limit the possibility to tailor particle production towards real-world applications. Herein we demonstrate that monodispersed MNs can be produced in a highly concentrated substrate solution within seconds for the first time, by microfluidic technique due to the precise control of superfast liquid mixing and mass transfer.Methods: The MNs were produced on a glass-capillary microfluidic chip, with a precise control over the particle formation and reaction termination. The particles were further encapsulated in a pH-responsive, endosomolytic polymer (MAP) by microfluidic technique, with anti-inflammatory drug budesonide loaded. The cellular uptake, endosomal escape behaviour, ROS scavenging capability, inflammatory cytokine release profile of these nanocomposites were evaluated on inflamed macrophages. Results: MNs with tunable sizes and monodispersity could be 1000 times faster than traditional bulk methods, confirmed by dynamic light scattering results and transmission electron microscopy images. Further characterizations by Fourier-transform infrared spectroscopy revealed that the MNs formed have similar chemical composition compared with those prepared by bulk method. The MNs show negligible cytotoxicity towards human and murine macrophages and ROS scavenging capacity. The encapsulation in MAP facilitated the endosomal escape and the intracellular delivery of MN, thus enhancing the uptake and ROS scavenging efficacy. The co-delivery of budesonide with MN by MAP reduced the expression of pro-inflammatory cell makers and induced the secretion of immune-suppressive cytokines interleukin-10, thus modulating the phenotype of macrophages from pro-inflammatory to anti-inflammatory.Conclusion: The simple, but advanced preparation of nanoparticles by microfluidic device, along with the endosomal escape capability, pH-controlled drug release profile, and efficient ROS scavenging property of the nanocomposites makes the nanosystems developed here a promising candidate for anti-inflammation therapy.Acknowledgements: This work was supported by grants from Jenny and Antti Wihuri Foundation, Thailand Research Fund, Finnish Culture Foundation, the HiLIFE Research Funds, the Sigrid Jusélius Foundation, the Norwegian Research Council/Nacamed AS, and the European Research Council.References (up to three): (1) S. I. Grivennikov, F. R. Greten, M. Karin, Cell, 2010: 883-899. (2) B. L. L. Seagle, E. M. Gasyna, W. F. Mieler, J. R. Norris, Proc. Natl. Acad. Sci., 2006: 16644-16648. (3) M. Mittal, M. R. Siddiqui, K. Tran, S. P. Reddy, A. B. Malik, Antioxid. Redox Signal., 2014: 1126-1167.