| People | Locations | Statistics |
|---|---|---|
| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Mccoy, Colin P.
Queen's University Belfast
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (7/7 displayed)
- 2023The effects of surfactants on the performance of polymer-based microwave-induced in situ amorphizationcitations
- 2022A biodegradable and antimicrobial polymer coating for metal implants for the prevention of prosthetic joint infectioncitations
- 2021Investigation into the role of the polymer in enhancing microwave-induced in situ amorphizationcitations
- 2020Multifunctional, low friction, antimicrobial approach for biomaterial surface enhancementcitations
- 2017Swellable polymer films containing Au nanoparticles for point-of-care therapeutic drug monitoring using surface-enhanced Raman spectroscopycitations
- 2015Novel Supercritical Carbon Dioxide Impregnation Technique for the Production of Amorphous Solid Drug Dispersions: A Comparison to Hot Melt Extrusioncitations
- 2010Moisture-Activated Rheological Structuring of Nonaqueous Poloxamine–Poly(Acrylic Acid) Systems Designed as Novel Biomedical Implantscitations
Places of action
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article
A biodegradable and antimicrobial polymer coating for metal implants for the prevention of prosthetic joint infection
Abstract
The aim of this project is to produce antibiotic-loaded poly (lactic-co-glycolic acid) (PLGA) polymer films by airbrush onto orthopaedic implants to address prosthetic joint infections (PJIs). It covered the development of an airbrush spray-coating technique, the selection and assessment of polymers and antibiotics, sample characterisation and antibacterial studies. The initial results are encouraging as the PLGA coatings exhibited a sustained drug release pattern and antibacterial ability against causative pathogens. Moreover, these PLGA coatings also possessed rapid degradation within 4 weeks which could provide favourable conditions for osseointegration. Furthermore, cytotoxicity assessment of final coatings will need to be conducted to ensure biocompatibility, as well as to determine the effect of each coating on osseointegration. Finally, the development of alternative coating techniques which are more cost-effective and suitable for large-scale production might be the direction of future research. <br/><br/>