| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Singh, Jagtar
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (8/8 displayed)
- 2019Nano scratch and Nanoindentation: An Approach to Understand the Tribological Behaviour of Max Phase Material Ti<sub>2</sub>AlCcitations
- 2018A novel study to examine the association of PCSK9 rs505151 polymorphism and coronary artery disease in north Indian population.citations
- 2014High risk association of IL-4 VNTR polymorphism with asthma in a North Indian population.citations
- 2014Association of 24 bp duplication of human CHIT1 gene with asthma in a heterozygous population of north India: a case-control study.citations
- 2012Genetic polymorphisms in the P2X7 gene and its association with susceptibility to tuberculosis.citations
- 2012Protective role of IL-18 -137G/C polymorphism in a North Indian population with asthma: a pilot study.citations
- 2011No Association of<i>PTGDR</i><i>−441C/T</i>Polymorphism with Asthma in a North Indian Populationcitations
- 2011No association of PTGDR -441C/T polymorphism with asthma in a North Indian population.citations
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article
Genetic polymorphisms in the P2X7 gene and its association with susceptibility to tuberculosis.
Abstract
BACKGROUND: Several studies have reported the influence of genetic variations on susceptibility to tuberculosis (TB). Polymorphism in P2X7 gene coding for P2X7 receptor present on macrophages has been linked to TB in different populations. OBJECTIVE: To assess the role of P2X7 gene -762T/C and -1513A/C polymorphisms in TB susceptibility. DESIGN: In a case-control study, polymerase chain reaction (PCR) amplification of genomic DNA extracted from peripheral blood samples of cases and controls was followed by restriction fragment length polymorphism or allele-specific PCR. RESULTS: The 1513C allele was found to be associated with TB susceptibility (P = 0.02, OR for variant C allele 1.33, 95%CI 1.03-1.73). A significant protective association against TB was found for -762T/C polymorphism (P < 0.01, OR for variant C allele 0.72, 95%CI 0.57-0.91). On classifying samples on the basis of sex, only males showed a significant association between P2X7 -1513A/C and P2X7 -762T/C and TB in the present study. CONCLUSION: A significant association of 762T/C and 1513A/C polymorphisms with TB in the P2X7 gene was found in our study population. A sex bias, with only males showing a significant association with the disease, is the first report of this kind. Genetic studies for the characterisation of the susceptibility genes can help to gain a better understanding of TB pathogenesis.