| People | Locations | Statistics |
|---|---|---|
| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Malda, Jos
Utrecht University
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (39/39 displayed)
- 2024Covalent Grafting of Functionalized MEW Fibers to Silk Fibroin Hydrogels to Obtain Reinforced Tissue Engineered Constructscitations
- 2024Covalent Grafting of Functionalized MEW Fibers to Silk Fibroin Hydrogels to Obtain Reinforced Tissue Engineered Constructscitations
- 20243D Printed Magneto-Active Microfiber Scaffolds for Remote Stimulation and Guided Organization of 3D In Vitro Skeletal Muscle Modelscitations
- 20233D printed magneto-active microfiber scaffolds for remote stimulation of 3D in vitro skeletal muscle modelscitations
- 20233D Printed Magneto‐Active Microfiber Scaffolds for Remote Stimulation and Guided Organization of 3D In Vitro Skeletal Muscle Modelscitations
- 20233D printed and punched porous surfaces of a non-resorbable, biphasic implant for the repair of osteochondral lesions improves repair tissue adherence and ingrowth
- 2023Composite Graded Melt Electrowritten Scaffolds for Regeneration of the Periodontal Ligament-to-Bone Interfacecitations
- 2021The Complexity of Joint Regeneration: How an Advanced Implant could Fail by Its In Vivo Proven Bone Componentcitations
- 2020Rapid and cytocompatible cell-laden silk hydrogel formation via riboflavin-mediated crosslinking
- 2020Rapid and cytocompatible cell-laden silk hydrogel formation via riboflavin-mediated crosslinkingcitations
- 2020Anisotropic hygro-expansion in hydrogel fibers owing to uniting 3D electrowriting and supramolecular polymer assemblycitations
- 2020A Multifunctional Nanocomposite Hydrogel for Endoscopic Tracking and Manipulationcitations
- 2020A composite hydrogel-3D printed thermoplast osteochondral anchor as an example for a zonal approach to cartilage repair: in vivo performance in a long-term equine modelcitations
- 2020Combining multi-scale 3D printing technologies to engineer reinforced hydrogel-ceramic interfacescitations
- 2020Combining multi-scale 3D printing technologies to engineer reinforced hydrogel-ceramic interfacescitations
- 2020Long-Term in Vivo Performance of Low-Temperature 3D-Printed Bioceramics in an Equine Modelcitations
- 2020Stable and Antibacterial Magnesium-Graphene Nanocomposite-Based Implants for Bone Repaircitations
- 2020Stable and Antibacterial Magnesium-Graphene Nanocomposite-Based Implants for Bone Repaircitations
- 2020Using 3D-printing to fabricate a microfluidic vascular model to mimic arterial thrombosis
- 2020Orthotopic Bone Regeneration within 3D Printed Bioceramic Scaffolds with Region-Dependent Porosity Gradients in an Equine Modelcitations
- 2020Orthotopic Bone Regeneration within 3D Printed Bioceramic Scaffolds with Region-Dependent Porosity Gradients in an Equine Model
- 2019T2* and quantitative susceptibility mapping in an equine model of post-traumatic osteoarthritis: assessment of mechanical and structural properties of articular cartilage
- 2019Bi-layered micro-fibre reinforced hydrogels for articular cartilage regeneration
- 2019Bi-layered micro-fibre reinforced hydrogels for articular cartilage regenerationcitations
- 2019Arthroscopic determination of cartilage proteoglycan content and collagen network structure with near-infrared spectroscopycitations
- 2019A Stimuli-Responsive Nanocomposite for 3D Anisotropic Cell-Guidance and Magnetic Soft Roboticscitations
- 2019Volumetric Bioprinting of Complex Living-Tissue Constructs within Secondscitations
- 2018Out-of-plane 3D-printed microfibers improve the shear properties of hydrogel composites
- 2018Out-of-plane 3D-printed microfibers improve the shear properties of hydrogel compositescitations
- 2018Out-of-Plane 3D-Printed Microfibers Improve the Shear Properties of Hydrogel Compositescitations
- 2017Assessing bioink shape fidelity to aid material development in 3D bioprintingcitations
- 2017Triblock copolymers based on ε-caprolactone and trimethylene carbonate for the 3D printing of tissue engineering scaffoldscitations
- 2017Triblock copolymers based on epsilon-caprolactone and trimethylene carbonate for the 3D printing of tissue engineering scaffoldscitations
- 2017Mimicking arterial thrombosis in a 3D-printed microfluidic in vitro vascular model based on computed tomography angiography datacitations
- 2016A thermo-responsive and photo-polymerizable chondroitin sulfate-based hydrogel for 3D printing applicationscitations
- 2016Yield stress determines bioprintability of hydrogels based on gelatin-methacryloyl and gellan gum for cartilage bioprintingcitations
- 2014Development and characterisation of a new bioink for additive tissue manufacturingcitations
- 2014Covalent attachment of a three-dimensionally printed thermoplast to a gelatin hydrogel for mechanically enhanced cartilage constructscitations
- 2014Covalent attachment of a three-dimensionally printed thermoplast to a gelatin hydrogel for mechanically enhanced cartilage constructs
Places of action
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article
Triblock copolymers based on ε-caprolactone and trimethylene carbonate for the 3D printing of tissue engineering scaffolds
Abstract
BACKGROUND: Biodegradable PCL-b-PTMC-b-PCL triblock copolymers based on trimethylene carbonate (TMC) and ε-caprolactone (CL) were prepared and used in the 3D printing of tissue engineering scaffolds. Triblock copolymers of various molecular weights containing equal amounts of TMC and CL were prepared. These block copolymers combine the low glass transition temperature of amorphous PTMC (approximately -20°C) and the semi-crystallinity of PCL (glass transition approximately -60°C and melting temperature approximately 60°C). METHODS: PCL-b-PTMC-b-PCL triblock copolymers were synthesized by sequential ring opening polymerization (ROP) of TMC and ε-CL. From these materials, films were prepared by solvent casting and porous structures were prepared by extrusion-based 3D printing. RESULTS: Films prepared from a polymer with a relatively high molecular weight of 62 kg/mol had a melting temperature of 58°C and showed tough and resilient behavior, with values of the elastic modulus, tensile strength and elongation at break of approximately 120 MPa, 16 MPa and 620%, respectively. Porous structures were prepared by 3D printing. Ethylene carbonate was used as a crystalizable and water-extractable solvent to prepare structures with microporous strands. Solutions, containing 25 wt% of the triblock copolymer, were extruded at 50°C then cooled at different temperatures. Slow cooling at room temperature resulted in pores with widths of 18 ± 6 μm and lengths of 221 ± 77 μm, rapid cooling with dry ice resulted in pores with widths of 13 ± 3 μm and lengths of 58 ± 12 μm. These PCL-b-PTMC-b-PCL triblock copolymers processed into porous structures at relatively low temperatures may find wide application as designed degradable tissue engineering scaffolds. CONCLUSIONS: In this preliminary study we prepared biodegradable triblock copolymers based on 1,3-trimethylene carbonate and ε-caprolactone and assessed their physical characteristics. Furthermore, we evaluated their potential as melt-processable thermoplastic elastomeric ...