| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Kellomäki, Minna
Tampere University of Technology
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (31/31 displayed)
- 2024A comprehensive study on rheological properties of photocrosslinkable gallol-metal complexed hyaluronic acid-based biomaterial inkscitations
- 2023Comprehensive characterisation of the compressive behaviour of hydrogels using a new modelling procedure and redefining compression testingcitations
- 2023Interpretable machine learning methods for monitoring polymer degradation in extrusion of polylactic acidcitations
- 2023Hydrolytic degradation of polylactide/polybutylene succinate blends with bioactive glasscitations
- 2023Chemical interactions in composites of gellan gum and bioactive glass: self-crosslinking and in vitro dissolutioncitations
- 2022Fractal-like Hierarchical CuO Nano/Microstructures for Large-Surface-to-Volume-Ratio Dip Catalystscitations
- 2022Injectable and self-healing biobased composite hydrogels as future anticancer therapeutic biomaterialscitations
- 2021Comprehensive characterisation of the compressive behaviour of hydrogels using a new modelling procedure and redefining compression testingcitations
- 2021Impact of glass composition on hydrolytic degradation of polylactide/bioactive glass compositescitations
- 2021In vitro degradation testing of hydrogels – concept and case study of gellan gum degradation in water
- 2020Evaluation of scaffold microstructure and comparison of cell seeding methods using micro-computed tomography-based toolscitations
- 2020Materials and Orthopedic Applications for Bioresorbable Inductively Coupled Resonance Sensorscitations
- 2020A tube-source X-ray microtomography approach for quantitative 3D microscopy of optically challenging cell-cultured samplescitations
- 2019Hydrolysis and drug release from poly(ethylene glycol)-modified lactone polymers with open porositycitations
- 2019Gas-foamed poly(lactide-co-glycolide) and poly(lactide-co-glycolide) with bioactive glass fibres demonstrate insufficient bone repair in lapine osteochondral defectscitations
- 2019Characterization of the microstructure of hydrazone crosslinked polysaccharide-based hydrogels through rheological and diffusion studiescitations
- 2019Characterization of the microstructure of hydrazone crosslinked polysaccharide-based hydrogels through rheological and diffusion studiescitations
- 2018Knitted 3D Scaffolds of Polybutylene Succinate Support Human Mesenchymal Stem Cell Growth and Osteogenesiscitations
- 2018Cell response to round and star-shaped polylactide fibers
- 2018Bioresorbable Conductive Wire with Minimal Metal Contentcitations
- 2017In vitro degradation of borosilicate bioactive glass and poly(L-lactide-co-ε-caprolactone) composite scaffoldscitations
- 2016Piezoelectric sensitivity of a layered film of chitosan and cellulose nanocrystalscitations
- 2016Inductively coupled passive resonance sensor for monitoring biodegradable polymers in vitrocitations
- 2016X-ray microtomography of collagen and polylactide samples in liquidscitations
- 2014Direct laser writing of synthetic poly(amino acid) hydrogels and poly(ethylene glycol) diacrylates by two-photon polymerizationcitations
- 2013Novel polypyrrole-coated polylactide scaffolds enhance adipose stem cell proliferation and early osteogenic differentiationcitations
- 2013An in vitro study of composites of poly(L-lactide-co-e-caprolactone), ß-tricalcium phosphate and ciprofloxacin intended for local treatment of osteomyelitiscitations
- 2012Processing and sustained in vitro release of rifampicin containing composites to enhance the treatment of osteomyelitiscitations
- 2011Knitted polylactide 96/4 L/D structures and scaffolds for tissue engineeringcitations
- 2011Investigation of the optimal processing parameters for picosecond laser-induced microfabrication of a polymer-ceramic hybrid materialcitations
- 2008Nano-, Pico- and femtosecond laser machining of bioabsorbable polymers and biomedical composites
Places of action
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article
An in vitro study of composites of poly(L-lactide-co-e-caprolactone), ß-tricalcium phosphate and ciprofloxacin intended for local treatment of osteomyelitis
Abstract
Osteomyelitis is a bacterial disease that can become chronic, and treatment often includes a surgical operation to remove infected bone. The aim of this study was to develop and investigate in vitro bone filling composite materials that release ciprofloxacin to kill any remaining bacteria and contain bioceramic to help the bone to heal. Three composites of poly(Llactide-co-ε-caprolactone), β-tricalcium phosphate and ciprofloxacin were compounded using twin-screw extrusion and sterilized by gamma irradiation. Drug release and degradation of the composites were investigated in vitro for 52 weeks. The composite with 50 wt% of β-TCP had the most promising ciprofloxacin release profile. The ceramic component accelerated the drug release that occurred in three phases obeying first-order kinetics. Inhibition zone testing using bioluminescence showed that the released ciprofloxacin had effect in eradicating a common osteomyelitis causing bacteria Pseudomonas aeruginosa. During the in vitro degradation test series, molar weight of the polymer matrix of the composites decreased rapidly. Additionally, 1H-NMR analysis showed that the polymer had blocky structure and the comonomer ratio changed during hydrolysis. The tested composites showed great potential to be developed into bone filler materials for the treatment of osteomyelitis or other bone related infections.