| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Seppälä, Jukka
Aalto University
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (42/42 displayed)
- 2024Polypyrrole-modified flax fiber sponge impregnated with fatty acids as bio-based form-stable phase change materials for enhanced thermal energy storage and conversioncitations
- 2024Polypyrrole-modified flax fiber sponge impregnated with fatty acids as bio-based form-stable phase change materials for enhanced thermal energy storage and conversioncitations
- 2024A cradle-to-gate life cycle assessment of polyamide-starch biocomposites: carbon footprint as an indicator of sustainabilitycitations
- 2023Strontium-Substituted Nanohydroxyapatite-Incorporated Poly(lactic acid) Composites for Orthopedic Applications: Bioactive, Machinable, and High-Strength Propertiescitations
- 2023Flexible and conductive nanofiber textiles for leakage-free electro-thermal energy conversion and storagecitations
- 2023Heat-Induced Actuator Fibers: Starch-Containing Biopolyamide Composites for Functional Textilescitations
- 2023High-concentration lignin biocomposites with low-melting point biopolyamidecitations
- 2023Innovative integration of pyrolyzed biomass into polyamide 11: Sustainable advancements through in situ polymerization for enhanced mechanical, thermal, and additive manufacturing propertiescitations
- 2022Injectable thiol-ene hydrogel of galactoglucomannan and cellulose nanocrystals in delivery of therapeutic inorganic ions with embedded bioactive glass nanoparticlescitations
- 2022Injectable thiol-ene hydrogel of galactoglucomannan and cellulose nanocrystals in delivery of therapeutic inorganic ions with embedded bioactive glass nanoparticlescitations
- 2022Injectable thiol-ene hydrogel of galactoglucomannan and cellulose nanocrystals in delivery of therapeutic inorganic ions with embedded bioactive glass nanoparticlescitations
- 2022Conductive polyurethane/PEGylated graphene oxide composite for 3D-printed nerve guidance conduitscitations
- 2021Exfoliated clay nanocomposites of renewable long-chain aliphatic polyamide through in-situ polymerizationcitations
- 2021Exfoliated clay nanocomposites of renewable long-chain aliphatic polyamide through in-situ polymerizationcitations
- 2021Sustainable composites of surface-modified cellulose with low-melting point polyamidecitations
- 2021Novel long-chain aliphatic polyamide/surface-modified silicon dioxide nanocomposites: in-situ polymerization and propertiescitations
- 2021Novel long-chain aliphatic polyamide/surface-modified silicon dioxide nanocomposites: in-situ polymerization and propertiescitations
- 2021Selective Laser Sintering of Lignin-Based Compositescitations
- 2021Selective Laser Sintering of Lignin-Based Compositescitations
- 2021High-Performance and Biobased Polyamide/Functionalized Graphene Oxide Nanocomposites through In Situ Polymerization for Engineering Applicationscitations
- 2021High-Performance and Biobased Polyamide/Functionalized Graphene Oxide Nanocomposites through In Situ Polymerization for Engineering Applicationscitations
- 2020Improved Bone Regeneration in Rabbit Bone Defects Using 3D Printed Composite Scaffolds Functionalized with Osteoinductive Factorscitations
- 20203D scaffolding of fast photocurable polyurethane for soft tissue engineering by stereolithography: Influence of materials and geometry on growth of fibroblast cellscitations
- 20203D Scaffolding of fast photocurable polyurethane for soft tissue engineering by stereolithographycitations
- 2019Hydrolysis and drug release from poly(ethylene glycol)-modified lactone polymers with open porositycitations
- 2019Multiscale Structural Characterization of Biocompatible Poly(trimethylene carbonate) Photoreticulated Networkscitations
- 2019Mechanical properties of ultraviolet-assisted paste extrusion and postextrusion ultraviolet-curing of three-dimensional printed biocompositescitations
- 2018Low-temperature rheological and morphological characterization of SBS modified bitumencitations
- 2018An empirical constitutive model for complex glass-forming liquids using bitumen as a model materialcitations
- 2017Highly active platinum nanoparticles supported by nitrogen/sulfur functionalized graphene composite for ethanol electro-oxidationcitations
- 2016Development of nanocellulose scaffolds with tunable structures to support 3D cell culturecitations
- 2015Tailor-made hemicellulose-based hydrogels reinforced with nanofibrillated cellulosecitations
- 2015Interdiffusion and Spinodal Decomposition in Electrically Conducting Polymer Blendscitations
- 2015Composite films of nanofibrillated cellulose and O-acetyl galactoglucomannan (GGM) coated with succinic esters of GGM showing potential as barrier material in food packagingcitations
- 2015Fabrication of graphene-based 3D structures by stereolithographycitations
- 2014Nanofibrillated cellulose, poly(vinyl alcohol), montmorillonite clay hybrid nanocomposites with superior barrier and thermomechanical propertiescitations
- 2013An in vitro study of composites of poly(L-lactide-co-e-caprolactone), ß-tricalcium phosphate and ciprofloxacin intended for local treatment of osteomyelitiscitations
- 2012Processing and sustained in vitro release of rifampicin containing composites to enhance the treatment of osteomyelitiscitations
- 2011Chemical modification of fine paper base with amphiphilic copolymercitations
- 2006Poly(vinyl alcohol) and polyamide-66 nanocomposites prepared by electrospinningcitations
- 2006High-molar-mass polypropene with tunable elastic properties by hafnocene/borate catalystscitations
- 2002Effect of glycerol on behaviour of amylose and amylopectin filmscitations
Places of action
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article
Processing and sustained in vitro release of rifampicin containing composites to enhance the treatment of osteomyelitis
Abstract
The objective in this study was to develop an osteoconductive, biodegradable and rifampicin releasing bone filling composite material for the treatment of osteomyelitis, a bacterial infection of bone that is very difficult and expensive to treat. The composite material will be used together with a ciprofloxacin releasing composite, because of the rapid development of resistant bacteria when rifampicin is used alone. Three composites were manufactured by twin-screw extrusion. The polymer matrix for the composites was poly(L-lactide-co-ε-caprolactone) 70/30 and all the composites contained 8 wt% (weight percent) of rifampicin antibiotic. The b-TCP contents of the composites were 0 wt%, 50 wt% and 60 wt%. The composites were sterilized by gamma irradiation before in vitro degradation and drug release tests. The hydrolytical degradation of the studied composites proceeded quickly and the molecular weight of the polymer component of the composites decreased rapidly. Rifampicin release occurred in four phases in which the high b-TCP content of the samples, polymer degradation and mass loss all played a role in determining the phases. The ceramic component was seen to have a positive effect on the drug release. The composite with 50 wt% of b-TCP showed the most promising rifampicin release profile and it also showed activity against a common osteomyelitis causing bacteria Pseudomonas aeruginosa. A clear inhibition zone was formed in 16 h incubation. Overall, the tested materials showed great potential to be developed into a bone filler material for the treatment of osteomyelitis or other bone related infections in combination with the ciprofloxacin releasing materials. ; Peer reviewed