| People | Locations | Statistics |
|---|---|---|
| Naji, M. |
| |
| Motta, Antonella |
| |
| Aletan, Dirar |
| |
| Mohamed, Tarek |
| |
| Ertürk, Emre |
| |
| Taccardi, Nicola |
| |
| Kononenko, Denys |
| |
| Petrov, R. H. | Madrid |
|
| Alshaaer, Mazen | Brussels |
|
| Bih, L. |
| |
| Casati, R. |
| |
| Muller, Hermance |
| |
| Kočí, Jan | Prague |
|
| Šuljagić, Marija |
| |
| Kalteremidou, Kalliopi-Artemi | Brussels |
|
| Azam, Siraj |
| |
| Ospanova, Alyiya |
| |
| Blanpain, Bart |
| |
| Ali, M. A. |
| |
| Popa, V. |
| |
| Rančić, M. |
| |
| Ollier, Nadège |
| |
| Azevedo, Nuno Monteiro |
| |
| Landes, Michael |
| |
| Rignanese, Gian-Marco |
|
Kaur, Mandeep
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (7/7 displayed)
- 2024Understanding and tuning the electronic structure of pentalenidescitations
- 2023Impact of Interleukin-10 Promoter Region Polymorphisms on Recurrent Miscarriage: A Case-Control Approach.citations
- 2022Association analysis of LHCGR variants and polycystic ovary syndrome in Punjab: a case–control approachcitations
- 2019Shelf life extension of vacuum packaged chilled beef in the Chinese supply chain. A feasibility study
- 2016Development of electrosynthetic methods for the functionalisation of tertiary amides
- 2014Cytotoxicity and apoptosis induced by a plumbagin derivative in estrogen positive MCF-7 breast cancer cellscitations
- 2012Thermally stable ferrocenyl "push-pull" chromophores with tailorable and switchable second-order non-linear optical response: synthesis and structure-property relationshipcitations
Places of action
| Organizations | Location | People |
|---|
article
Impact of Interleukin-10 Promoter Region Polymorphisms on Recurrent Miscarriage: A Case-Control Approach.
Abstract
<h4>Background</h4>Recurrent miscarriage (RM), defined as two or more consecutive miscarriages prior to the 20<sup>th</sup> week of gestation is characterised by multifactorial aetiology. The prevalence of RM varies from 0.8% to 13.5% amongst women of reproductive age. The aetiological basis of RM has been traced to chromosomal, anatomic, hormonal and immunologic factors while half of the cases remain idiopathic.<h4>Aims</h4>This study aimed to investigate the association of interleukin-10 (IL-10) polymorphisms with RM amongst the Indian population.<h4>Settings and design</h4>The present study included a total of 414 individuals including RM women (<i>n</i> = 199) with two or more pregnancy losses and healthy women (<i>n</i> = 215) without any previous history of pregnancy loss were taken as the control group.<h4>Materials and methods</h4>Demographic features and reproductive history of women with RM and healthy women were taken. Genotype analysis of IL-10 polymorphisms rs1800872 and rs1800896 was performed using the polymerase chain reaction (PCR) restriction fragment length polymorphism and amplification mutation refractory system PCR, respectively.<h4>Statistical analysis used</h4>Student's <i>t</i>-test was used to compare the demographic features and reproductive history amongst both groups. Pearson's Chi-square was used to calculate the Hardy-Weinberg equilibrium, allelic and genotypic frequencies. All the statistical analyses were performed using the SPSS (version 21, IBM SPSS, NY, USA).<h4>Results</h4>Our results suggested that the genotypic and allelic frequency of rs1800872 polymorphism did not differ significantly between RM cases and control women (<i>P</i> = 0.07 and <i>P</i> = 0.23, respectively). The GG genotype (<i>P</i> = 0.007) and G allele (<i>P</i> = 0.003) of rs1800896 were significantly associated with an increased risk of RM. A statistically significant difference was also found for the distribution of genetic models (dominant and co-dominant model) between both groups for rs1800896. However, haplotype analysis revealed that none of the haplotypes provides a risk for the progression of RM.<h4>Conclusion</h4>The study is the first of its kind from our region and provides baseline data on the genetics of RM.