• Singh, Ruchi
• Patil, Shivanand
• Hiremath, Shobha G.
• Patil, Giramalla
• Siddhanta, Soumik

Abstract

<jats:title>Abstract</jats:title><jats:sec><jats:title>BACKGROUND:</jats:title><jats:p>The <jats:italic toggle="yes">Tridhaatu Garbha Pottali</jats:italic> (TGP) <jats:italic toggle="yes">Rasayana</jats:italic> is a formulation that may not be widely known, but it is prepared using the <jats:italic toggle="yes">Gandhaka Drava Paka</jats:italic> method of <jats:italic toggle="yes">Pottali</jats:italic> preparation. It has been reportedly used in the treatment of various conditions, including <jats:italic toggle="yes">Putimeha</jats:italic> (<jats:italic toggle="yes">Pyorrhea</jats:italic>), <jats:italic toggle="yes">Pradara</jats:italic> (<jats:italic toggle="yes">Leukorrhea</jats:italic>), and <jats:italic toggle="yes">Shukra Dosha</jats:italic> (seminal abnormalities). Despite its potential benefits, no current research is being conducted on the synthesis and characterization of this formulation. An attempt was made to standardize the method of preparation of TGP <jats:italic toggle="yes">Rasayana</jats:italic> as mentioned in <jats:italic toggle="yes">Rasayogasagar</jats:italic> (a classical text of <jats:italic toggle="yes">Rasashastra</jats:italic>), and nanoparticle (NP) characterization was carried out alongside classical and physicochemical parameters. Presesent study aimed to standardize TGP Rasayana preparation method and analyze for Nanoparticle Characterization.</jats:p></jats:sec><jats:sec><jats:title>METHODS:</jats:title><jats:p>TGP <jats:italic toggle="yes">Rasayana</jats:italic> is a <jats:italic toggle="yes">Pottali Rasayana</jats:italic> prepared using the <jats:italic toggle="yes">Gandhaka Paaka</jats:italic> technique, amalgamating <jats:italic toggle="yes">Shuddha Parada</jats:italic>, <jats:italic toggle="yes">Shuddha Swarna</jats:italic>, <jats:italic toggle="yes">Shuddha Gandhaka</jats:italic>, along with <jats:italic toggle="yes">Bhasmas</jats:italic> of <jats:italic toggle="yes">Naga</jats:italic>, <jats:italic toggle="yes">Vanga</jats:italic>, and <jats:italic toggle="yes">Yashadha</jats:italic>. <jats:italic toggle="yes">Swarna-Parada Dhatu Pishti</jats:italic> (fusion) was prepared first, followed by the addition of <jats:italic toggle="yes">Gandhaka</jats:italic>. Then, the <jats:italic toggle="yes">Bhasmas</jats:italic> of <jats:italic toggle="yes">Naga</jats:italic>, <jats:italic toggle="yes">Vanga</jats:italic>, and <jats:italic toggle="yes">Yashada</jats:italic> were added, well mixed using trituration method, and <jats:italic toggle="yes">Kumari Swarasa Bhavana</jats:italic> was administered. The resulting TGP <jats:italic toggle="yes">Kajjali</jats:italic> was given a conical shape and dried, and <jats:italic toggle="yes">Pottali</jats:italic> was wrapped in four-folded silk material with <jats:italic toggle="yes">Gandhaka</jats:italic> in between. <jats:italic toggle="yes">Pottali Paka</jats:italic> was performed in <jats:italic toggle="yes">Mritpatra</jats:italic> using the <jats:italic toggle="yes">Gandhaka Paaka</jats:italic> method, placing it in a <jats:italic toggle="yes">Valuka Yantra</jats:italic> and subjecting it to <jats:italic toggle="yes">Mridvagni</jats:italic> for 8 h to obtain all <jats:italic toggle="yes">Pottali Siddha Lakshana</jats:italic>. Then, the obtained TGP <jats:italic toggle="yes">Rasayana</jats:italic> was analyzed for classical and instrumental parameters, physicochemical parameters, and sophisticated instrumental analyses such as X-ray diffraction (XRD), scanning electron microscopy (SEM), energy-dispersive X-ray (EDX), Fourier transform infrared spectroscopy (FTIR), and Raman spectra.</jats:p></jats:sec><jats:sec><jats:title>RESULTS:</jats:title><jats:p>TGP possessed all classical parameters of <jats:italic toggle="yes">Pottali</jats:italic>. XRD confirms the presence of HgS, PbS, SnO<jats:sub>2</jats:sub>, and ZnO. SEM images show the agglomerated appearance of TGP particles. Energy dispersive X-ray analysis (EDAX) confirms the presence of sulfur, zinc, tin, mercury, and lead as major elements, with gold as minor elements. FTIR shows the presence of organic sulphate, aliphatic amines, and alkyl halides.</jats:p></jats:sec><jats:sec><jats:title>CONCLUSION:</jats:title><jats:p>The TGP <jats:italic toggle="yes">Rasayana</jats:italic> that has been prepared contains various NPs that possess functional groups, thus making it a highly effective therapeutic medicine with the properties of nanomedicine.</jats:p></jats:sec>

Topics

• nanoparticle
• impedance spectroscopy
• scanning electron microscopy
• x-ray diffraction
• zinc
• gold
• Energy-dispersive X-ray spectroscopy
• size-exclusion chromatography
• tin
• amine
• Fourier transform infrared spectroscopy
• Mercury