| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Van Blitterswijk, Clemens A.
Maastricht University
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (21/21 displayed)
- 2023Direct deep UV lithography to micropattern PMMA for stem cell culturecitations
- 2023Polymer film-based microwell array platform for long-term culture and research of human bronchial organoidscitations
- 2023Complementary Supramolecular Functionalization Enhances Antifouling Surfacescitations
- 2022Assessment of Cell-Material Interactions in Three Dimensions through Dispersed Coaggregation of Microsized Biomaterials into Tissue Spheroidscitations
- 2021Bioprinting Via a Dual-Gel Bioink Based on Poly(Vinyl Alcohol) and Solubilized Extracellular Matrix towards Cartilage Engineeringcitations
- 2021Thin fluorinated polymer film microcavity arrays for 3D cell culture and label-free automated feature extractioncitations
- 2017Development of a microfluidic platform integrating high-resolution microstructured biomaterials to study cell-material interactionscitations
- 2016Mimicking natural cell environments: design, fabrication and application of bio-chemical gradients on polymeric biomaterial substratescitations
- 2016Surface energy and stiffness discrete gradients in additive manufactured scaffolds for osteochondral regenerationcitations
- 2016The Effects of Crystal Phase and Particle Morphology of Calcium Phosphates on Proliferation and Differentiation of Human Mesenchymal Stromal Cellscitations
- 20163D high throughput screening and profiling of embryoid bodies in thermoformed microwell platescitations
- 2016Flexible Yttrium-Stabilized Zirconia Nanofibers Offer Bioactive Cues for Osteogenic Differentiation of Human Mesenchymal Stromal Cellscitations
- 2015Distribution and Viability of Fetal and Adult Human Bone Marrow Stromal Cells in a Biaxial Rotating Vessel Bioreactor after Seeding on Polymeric 3D Additive Manufactured Scaffoldscitations
- 2014A biocomposite of collagen nanofibers and nanohydroxyapatite for bone regenerationcitations
- 2010Biomimetic calcium phosphate coatings on recombinant spider silk fibrescitations
- 2008Comparative in vivo study of six hydroxyapatite-based bone graft substitutescitations
- 2007Biological performance in goats of a porous titanium alloy-biphasic calcium phosphate compositecitations
- 2006Influence of physico-chemical properties, macro- and microstructure on osteoinductive potential of calcium-phosphate ceramicscitations
- 2006Relevance of osteoinductive biomaterials in critical-sized orthotopic defectcitations
- 20053D microenvironment as essential element for osteoinduction by biomaterialscitations
- 2004Influence of octacalcium phosphate coating on osteoinductive properties of biomaterialscitations
Places of action
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article
Influence of physico-chemical properties, macro- and microstructure on osteoinductive potential of calcium-phosphate ceramics
Abstract
<p>Osteoinduction by biomaterials that initially do not contain bone morphogenetic proteins and other growth factors has been shown to be a real phenomenon by many investigators in the past two decades. Although it is well-known that a material needs to meet very specific requirements in terms of physico-chemical and structural properties in order to be osteoinductive, the underlying mechanism of osteoinduction is not fully unraveled yet. In the present study we investigated parameters which are of importance for the osteoinductive potential of biomaterials by comparing four biphasic calcium-phosphate and a carbonated apatite ceramic. The results showed that the presence of micropores, by which the specific surface area of a material is increased, is essential for the material's osteoinductivity. However, if the surface area is too high, or material is too resorbable because of its chemical composition, the implant might degrade and lose its shape. In that case, ectopic bone formation does not occur, as a relatively stable surface is needed to facilitate new bone growth.</p>