| People | Locations | Statistics |
|---|---|---|
| Naji, M. |
| |
| Motta, Antonella |
| |
| Aletan, Dirar |
| |
| Mohamed, Tarek |
| |
| Ertürk, Emre |
| |
| Taccardi, Nicola |
| |
| Kononenko, Denys |
| |
| Petrov, R. H. | Madrid |
|
| Alshaaer, Mazen | Brussels |
|
| Bih, L. |
| |
| Casati, R. |
| |
| Muller, Hermance |
| |
| Kočí, Jan | Prague |
|
| Šuljagić, Marija |
| |
| Kalteremidou, Kalliopi-Artemi | Brussels |
|
| Azam, Siraj |
| |
| Ospanova, Alyiya |
| |
| Blanpain, Bart |
| |
| Ali, M. A. |
| |
| Popa, V. |
| |
| Rančić, M. |
| |
| Ollier, Nadège |
| |
| Azevedo, Nuno Monteiro |
| |
| Landes, Michael |
| |
| Rignanese, Gian-Marco |
|
Ozaltin, Kadir
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (11/11 displayed)
- 2021Effects of chitosan/chondroitin sulfate polysaccharide lids on amoxicillin drug release from microcontainers
- 2020Cell response to PLA scaffolds functionalized with various seaweed polysaccharidescitations
- 2020Biodegradable porous polylactic acid film as a separator for supercapacitorscitations
- 2019Anticoagulant polyethylene terephthalate surface by plasma-mediated fucoidan immobilizationcitations
- 2019Investigation of different severe plastic deformation methods effect on Ti13Nb13Zr
- 2019Tribological behavior of a hydrostatically extruded ultra-fine grained Ti-13Nb-13Zr alloycitations
- 2018Preparation of active antibacterial biomaterials based on sparfloxacin, enrofloxacin, and lomefloxacin deposited on polyethylenecitations
- 2017Microstructure and Texture Evolutions of Biomedical Ti-13Nb-13Zr Alloy Processed by Hydrostatic Extrusioncitations
- 2017A novel multistep method for chondroitin sulphate immobilization and its interaction with fibroblast cellscitations
- 2016Mechanical properties, structural and texture evolution of biocompatible Ti–45Nb alloy processed by severe plastic deformationcitations
- 2014Enhancement of mechanical properties of biocompatible Ti-45Nb alloy by hydrostatic extrusioncitations
Places of action
| Organizations | Location | People |
|---|
document
Effects of chitosan/chondroitin sulfate polysaccharide lids on amoxicillin drug release from microcontainers
Abstract
<p>Microcontainers are micrometer-sized cylindrical reservoir-based devices serving as drug carriers for oral administration systems with ensuring a high drug concentration at the desired site of absorption and providing a sustained resident time. These polymeric micro-cylinders consist of drug-filled cavities and can be functionalized by sealing with polymeric lids to protect the active pharmaceutical ingredient against degradation before reaching the absorption site. The present study aimed to develop biopolymer-based lids for microcontainers using polysaccharides for the prolonged release of an antibiotic. Amoxicillin was chosen as a model drug and loaded into microcontainers using the polydimethylsiloxane masking technique, followed by spray coating with chitosan (CS) and chondroitin sulfate (ChS) as polymeric lids onto the cavity of the devices. The structural and physicochemical properties of the microcontainers were investigated. Moreover, the effect of polysaccharide-based lids on the drug release behavior was further analysed and discussed. The thickness and morphology of the lids were characterized by profilometry and SEM before and after spray coating. The in vitro release profiles revealed a fast and an immediate release of amoxicillin from only ChS-coated microcontainers as in the uncoated ones, and slow, prolonged release from only CS-coated ones. However, the microcontainers with CS-ChS lids showed a biphasic release pattern that consists of a lesser burst release in the early stage of treatment, followed by a more sustained release. Therefore, the formation of polyelectrolytes between CS and ChS plays an important role in controlling the release process. The results suggest that the CS-ChS based lids for microcontainers can be useful in biodegradable, tailor-made controlled drug delivery systems.</p>