| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Lazzeri, Andrea
University of Pisa
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (58/58 displayed)
- 2024ON THE EFFECTS OF THE INTERPHASE ON THE DAMPING OF CFRP STRUCTURES: AN EXPERIMENTAL INVESTIGATION
- 2024Toughened Vinyl Ester Resin Reinforced with Natural Flax Fabrics
- 2023Chitin nanofibrils modulate mechanical response in tympanic membrane replacementscitations
- 2023Investigation of Novel Flax Fiber/Epoxy Composites with Increased Biobased Contentcitations
- 2023Investigation of Novel Flax Fiber/Epoxy Composites with Increased Biobased Contentcitations
- 2023A Straightforward Method to Produce Multi-Nanodrug Delivery Systems for Transdermal/Tympanic Patches Using Electrospinning and Electrospraycitations
- 2022Micromechanical Deformation Processes and Failure of PBS Based Composites Containing Ultra-Short Cellulosic Fibers for Injection Molding Applicationscitations
- 2022Size effect of carbon fiber-reinforced silicon carbide composites (C/C-SiC) : Part 2 - tensile testing with alignment devicecitations
- 2022Essential Work of Fracture and Evaluation of the Interfacial Adhesion of Plasticized PLA/PBSA Blends with the Addition of Wheat Bran By-Productcitations
- 2022Formulazioni polimeriche di colle a caldo di origine naturale per applicazioni come rivestimenti contenenti biomolecole attive
- 2021Polylactic Acid and Poly(Butylene Adipate-Co-Terephthalate) Blends Plasticised with Lactic Oligomers and Epoxy Reactive Plasticizers
- 2021New insights in bioplastics processing and recycling
- 2020Overview of Agro-Food Waste and by Products Valorization for Polymer Synthesis, and Modification for Bio-Composite Production.
- 2020Bio-Based Packaging: Materials, Modifications, Industrial Applications and Sustainabilitycitations
- 2020Electric field induced alignment of graphene oxide nanoplatelets in polyethersulfone matrixcitations
- 2019Thermal and Mechanical Properties of Biocomposites Made of Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) and Potato Pulp Powdercitations
- 2019Processability and degradability of PHA-based composites in terrestrial environmentscitations
- 2019Raw protein hydrolysates from tanning industry in blends with Polybutylene succinate adipate (PBSA) for agricultural applications
- 2019Thermal, Mechanical, and Rheological Properties of Biocomposites Made of Poly(lactic acid) and Potato Pulp Powdercitations
- 2019Rigid filler toughening in PLA-Calcium Carbonate composites: Effect of particle surface treatment and matrix plasticizationcitations
- 2019Chitin Nanofibrils in Poly(Lactic Acid) (PLA) Nanocomposites: Dispersion and Thermo-Mechanical Propertiescitations
- 2019Improved impact properties in poly(lactic acid) (PLA) blends containing cellulose acetate (CA) prepared by reactive extrusioncitations
- 2018Poly(lactic acid) (PLA) Based Tear Resistant and Biodegradable Flexible Films by Blown Film Extrusioncitations
- 2018Biopolyesters and bio based additives based blends and composites for application in packaging and agriculture
- 2018Effect of different nucleating agent on crystallinity and properties of polylactic acidcitations
- 2018Nano-calcite preparation aimed at consolidating stones for cultural heritage applicationscitations
- 2017Effect of nucleating agents on crystallinity and properties of poly (lactic acid) (PLA)citations
- 2017Effects of waviness on fiber-length distribution and interfacial shear strength of natural fibers reinforced compositescitations
- 2017New Bio-Composites Based on Polyhydroxyalkanoates and Posidonia oceanica Fibres for Applications in a Marine Environmentcitations
- 2017Reactively extruded ecocomposites based on poly(lactic acid)/bisphenol A polycarbonate blends reinforced with regenerated cellulose microfiberscitations
- 2016Processing routes for the preparation of poly(lactic acid)/cellulose-nanowhisker nanocomposites for packaging applications
- 2016Reactive extrusion of PLA/PC blends and composites
- 2016New Polymer Architectures for Architectural Stone Preservation
- 2016Composition dependence of the synergistic effect of nucleating agent and plasticizer in poly(lactic acid): a Mixture Design studycitations
- 2016Recent Advances in Biotechnology, Vol. 2citations
- 2016Thermal Properties of Plasticized Poly (Lactic Acid)(PLA) Containing Nucleating Agentcitations
- 2015EMPLOYMENT OF HIGH-FREQUENCY ELECTRO-MAGNETIC TECHNOLOGIES FOR COMPETITIVE PROCESSING OF CERAMIC MATRIX COMPOSITES AND GRAPHITE EXPANSION
- 2015Flexible polyurethane foams green production employing lignin or oxypropylated lignincitations
- 2015NATURAL NANO OR MICRO POLYSACCHARIDE FIBERS IN BIOPOLYESTERS MATRICES
- 2015Comparison of precipitated calcium carbonate/polylactic acid and halloysite/polylactic acid nanocompositescitations
- 2015Development of Fibres-Reinforced Biodegradable Composites
- 2014Modification of the mechanical behavior in the glass transition region of poly(lactic acid) (PLA) through catalyzed reactive extrusion with poly(carbonate) (PC)citations
- 2014EFFECT OF AGING TIME ON MECHANICAL PROPERTIES OF PLASTICIZED POLY(HYDROXYBUTYRATE) (PHB)citations
- 2014Dependence of the Pukánszky's interaction parameter B on the interface shear strength (IFSS) of nanofiller- and short fiber-reinforced polymer compositescitations
- 2013Green synthesis of flexible polyurethane foams from liquefied lignincitations
- 2012Properties of whey-protein-coated films and laminates as novel recyclable food packaging materials with excellent barrier propertiescitations
- 2012"Green" biocomposites based on cellulose diacetate and regenerated cellulose microfibers: Effect of plasticizer content on morphology and mechanical propertiescitations
- 2011Der Einfluss einer Oberflächenbeschichtung von gefälltem Calciumcarbonat auf die mechanischen Eigenschaften von polymeren Nanocomposites
- 2009Synthesis of Bioactive Hydroxyapatite-Zirconia Toughened Composites for Bone Replacementcitations
- 2008Synthesis of Bioactive Hydroxyapatite-Zirconia Toughened Composites for Bone Replacementcitations
- 2008Modeling and development of a microwave heated pilot plant for the production of SiC-based ceramic matrix composites
- 2007Effect of both uncoated and coated calcium carbonate on fracture toughness of HDPE/CaCO3 nanocompositescitations
- 2005Filler Toughening of Plastics. Part 1 - The Effect of Surface Interactions on Physico-Mechanical Properties and Rheological Behaviour of Ultrafine CaCO3/High Density Polyethylene Nanocompositescitations
- 2004Volume Strain Measurements on CaCO3/Polypropylene Particulate Composites: the Effect of Particle Sizecitations
- 2002The Role of the Interface on the Deformation Mechanism of Glass Fibers/Polypropylene Compositescitations
- 2001A Micromechanical Model for Multiple Crazing in High Impact Polystirenecitations
- 2000Colour Development during Devitrification in Li2O-ZnO-Al2O3-SiO2 Glasses under Conventional and Microwave Heating
- 2000Recent Developments in the Modeling of Dilatational Yielding in Toughened Plastics
Places of action
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article
A Straightforward Method to Produce Multi-Nanodrug Delivery Systems for Transdermal/Tympanic Patches Using Electrospinning and Electrospray
Abstract
<jats:p>The delivery of drugs through the skin barrier at a predetermined rate is the aim of transdermal drug delivery systems (TDDSs). However, so far, TDDS has not fully attained its potential as an alternative to hypodermic injections and oral delivery. In this study, we presented a proof of concept of a dual drug-loaded patch made of nanoparticles (NPs) and ultrafine fibers fabricated by using one equipment, i.e., the electrospinning apparatus. Such NP/fiber systems can be useful to release drugs locally through the skin and the tympanic membrane. Briefly, dexamethasone (DEX)-loaded poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBHV) fiber meshes were decorated with rhodamine (RHO)-loaded poly(lactic-co-glycolic acid) (PLGA) NPs, with RHO representing as a second drug model. By properly tuning the working parameters of electrospinning, DEX-loaded PHBHV fibers (i.e., by electrospinning mode) and RHO-loaded PLGA NPs (i.e., by electrospray mode) were successfully prepared and straightforwardly assembled to form a TDDS patch, which was characterized via Fourier transform infrared spectroscopy and dynamometry. The patch was then tested in vitro using human dermal fibroblasts (HDFs). The incorporation of DEX significantly reduced the fiber mesh stiffness. In vitro tests with showed that HDFs were viable for 8 days in contact with drug-loaded samples, and significant signs of cytotoxicity were not highlighted. Finally, thanks to a beaded structure of the fibers, a controlled release of DEX from the electrospun patch was obtained over 4 weeks, which may accomplish the therapeutic objective of a local, sustained and prolonged anti-inflammatory action of a TDDS, as is requested in chronic inflammatory conditions, and other pathological conditions, such as in sudden sensorineural hearing loss treatment.</jats:p>