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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Bartolo, Paulo
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (25/25 displayed)
- 2024Biomimetic dual sensing polymer nanocomposite for biomedical applicationscitations
- 2023Accelerated Degradation of Poly-ε-caprolactone Composite Scaffolds for Large Bone Defectscitations
- 2023Rheological behaviour of different composite materials for additive manufacturing of 3D bone scaffoldscitations
- 2022Smart nanostructured materials for tissue engineering
- 2021Green Synthesis of Silver Nanoparticles Using Extract of Cilembu Sweet Potatoes (Ipomoea batatas L var. Rancing) as Potential Filler for 3D Printed Electroactive and Anti-Infection Scaffoldscitations
- 2021In Vivo Investigation of Polymer-Ceramic PCL/HA and PCL/β-TCP 3D Composite Scaffolds and Electrical Stimulation for Bone Regenerationcitations
- 2020Mechanical, biological and tribological behaviour of fixation plates 3D printed by electron beam and selective laser meltingcitations
- 2014Materials characterization for stereolithography
- 2014Fabrication and characterisation of PCL and PCL/PLA scaffolds for tissue engineeringcitations
- 2011Theoretical and Modeling Aspects of Curing Reactionscitations
- 2011Biofabrication of poly(HEMA) scaffolds through stereolithography
- 2011Stereolithographic Processescitations
- 2011History of Stereolithographic Processescitations
- 2009Cristallinity and anisotropy evaluation of polymeric biomaterials for bioextrusion
- 2008Selective laser sintering
- 2007A new phenomenological model to describe the mechanical behaviour of alginate structures for tissue engineering
- 2006Effective modelling for thermoset systems
- 2005Direct and inverse stereolithography problem modeling
- 2005Modelling of reaction kinetic through stereolithography process
- 2005New approach to cure modelling for stereolithography
- 2004Modelling the curing behaviour and morphological studies of polymeric materials for thermal stereolithographic process
- 2003Kinetic modeling of reaction polymerization processes through RIM
- 2003Advanced photo-fabrication system for thermosetting materials
- 2002A new thermal-kinetic and mechanical modelling approach to study curing reactions of thermosetting materials
- 2001Stereolithography heat-transfer and solidification simulation using the finite element method
Places of action
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article
Accelerated Degradation of Poly-ε-caprolactone Composite Scaffolds for Large Bone Defects
Abstract
<jats:p>This research investigates the accelerated hydrolytic degradation process of both anatomically designed bone scaffolds with a pore size gradient and a rectangular shape (biomimetically designed scaffolds or bone bricks). The effect of material composition is investigated considering poly-ε-caprolactone (PCL) as the main scaffold material, reinforced with ceramics such as hydroxyapatite (HA), β-tricalcium phosphate (TCP) and bioglass at a concentration of 20 wt%. In the case of rectangular scaffolds, the effect of pore size (200 μm, 300 μm and 500 μm) is also investigated. The degradation process (accelerated degradation) was investigated during a period of 5 days in a sodium hydroxide (NaOH) medium. Degraded bone bricks and rectangular scaffolds were measured each day to evaluate the weight loss of the samples, which were also morphologically, thermally, chemically and mechanically assessed. The results show that the PCL/bioglass bone brick scaffolds exhibited faster degradation kinetics in comparison with the PCL, PCL/HA and PCL/TCP bone bricks. Furthermore, the degradation kinetics of rectangular scaffolds increased by increasing the pore size from 500 μm to 200 μm. The results also indicate that, for the same material composition, bone bricks degrade slower compared with rectangular scaffolds. The scanning electron microscopy (SEM) images show that the degradation process was faster on the external regions of the bone brick scaffolds (600 μm pore size) compared with the internal regions (200 μm pore size). The thermal gravimetric analysis (TGA) results show that the ceramic concentration remained constant throughout the degradation process, while differential scanning calorimetry (DSC) results show that all scaffolds exhibited a reduction in crystallinity (Xc), enthalpy (Δm) and melting temperature (Tm) throughout the degradation process, while the glass transition temperature (Tg) slightly increased. Finally, the compression results show that the mechanical properties decreased during the degradation process, with PCL/bioglass bone bricks and rectangular scaffolds presenting higher mechanical properties with the same design in comparison with the other materials.</jats:p>